MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis.
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Toward precision medicine in amyotrophic lateral sclerosisAutophagy and neurodegenerationTrehalose Accumulation Triggers Autophagy during Plant DesiccationAutophagy in neurodegenerative diseases: from mechanism to therapeutic approachEssential role for autophagy in life span extensionExploring new pathways of neurodegeneration in ALS: the role of mitochondria quality controlInterplay of Oxidative Stress and Autophagy in PAMAM Dendrimers-Induced Neuronal Cell DeathmTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseasesProtein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms.Defective autophagy is associated with neuronal injury in a mouse model of multiple sclerosisThe Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases.Synergic prodegradative activity of Bicalutamide and trehalose on the mutant androgen receptor responsible for spinal and bulbar muscular atrophy.Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease.Trehalose, an mTOR independent autophagy inducer, alleviates human podocyte injury after puromycin aminonucleoside treatment.Trehalose-mediated autophagy impairs the anti-viral function of human primary airway epithelial cells.Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse modelMitochondrial dynamic abnormalities in amyotrophic lateral sclerosis.Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.mRNP granules. Assembly, function, and connections with disease.p62 Pathology Model in the Rat Substantia Nigra with Filamentous Inclusions and Progressive NeurodegenerationTrehalose, an mTOR-Independent Inducer of Autophagy, Inhibits Human Cytomegalovirus Infection in Multiple Cell Types.Current Therapy of Drugs in Amyotrophic Lateral Sclerosis.Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway.Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression.Preservation of Cognitive Function by Lepidium meyenii (Maca) Is Associated with Improvement of Mitochondrial Activity and Upregulation of Autophagy-Related Proteins in Middle-Aged Mouse CortexSLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy.Targeting the unfolded protein response for disease intervention.mTOR in Brain Physiology and Pathologies.Congenital disorders of autophagy: an emerging novel class of inborn errors of neuro-metabolism.Old versus New Mechanisms in the Pathogenesis of ALS.A Central Role for Phosphorylated p38α in Linking Proteasome Inhibition-Induced Apoptosis and Autophagy.Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases.Target acquired: Selective autophagy in cardiometabolic disease.Autophagy in neurodegenerative diseases: pathogenesis and therapy.mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1.Fine-Tuning ER Stress Signal Transducers to Treat Amyotrophic Lateral Sclerosis.Cell Death-Autophagy Loop and Glutamate-Glutamine Cycle in Amyotrophic Lateral Sclerosis.Trehalose May Decrease the Transmission of Zika Virus to the Fetus by Activating Degradative Autophagy.Histone deacetylase 6 delays motor neuron degeneration by ameliorating the autophagic flux defect in a transgenic mouse model of amyotrophic lateral sclerosis.
P2860
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P2860
MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis.
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
MTOR-independent, autophagic e ...... amyotrophic lateral sclerosis.
@ast
MTOR-independent, autophagic e ...... amyotrophic lateral sclerosis.
@en
type
label
MTOR-independent, autophagic e ...... amyotrophic lateral sclerosis.
@ast
MTOR-independent, autophagic e ...... amyotrophic lateral sclerosis.
@en
prefLabel
MTOR-independent, autophagic e ...... amyotrophic lateral sclerosis.
@ast
MTOR-independent, autophagic e ...... amyotrophic lateral sclerosis.
@en
P2093
P2860
P921
P356
P1433
P1476
MTOR-independent, autophagic e ...... amyotrophic lateral sclerosis
@en
P2093
P2860
P304
P356
10.4161/AUTO.27710
P50
P577
2014-01-15T00:00:00Z