Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.

Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.

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http://www.wikidata.org/entity/Q36061223
Progranulin, lysosomal regulation and neurodegenerative disease.Induced Pluripotent Stem Cell Neuronal Models for the Study of Autophagy Pathways in Human Neurodegenerative Disease.Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy.Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia.Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations.Trehalose improves traumatic brain injury-induced cognitive impairment.Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer's Disease.An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations.Alagille syndrome: Genetics and Functional Models.Mining the transcriptome for rare disease therapies: a comparison of the efficiencies of two data mining approaches and a targeted cell-based drug screen.Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease.Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia.Trehalose Activates CRE-Dependent Transcriptional Signaling in HT22 Mouse Hippocampal Neuronal Cells: A Central Role for PKA Without cAMP Elevation
P2860

Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.

Item
http://www.wikidata.org/entity/Q36061223
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Trehalose upregulates progranu ...... treat frontotemporal dementia.
@ast
Trehalose upregulates progranu ...... treat frontotemporal dementia.
@en
type
label
Trehalose upregulates progranu ...... treat frontotemporal dementia.
@ast
Trehalose upregulates progranu ...... treat frontotemporal dementia.
@en
prefLabel
Trehalose upregulates progranu ...... treat frontotemporal dementia.
@ast
Trehalose upregulates progranu ...... treat frontotemporal dementia.
@en
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P2860
P2888
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Trehalose upregulates progranu ...... treat frontotemporal dementia.
@en
P2093
P2860
P2888
P304
P31
P356
P433
P478
P50
P577
P6179
P698
P921
P932