The design and application of target-focused compound libraries. - Wikidata - wikimedia - TriplyDB

The design and application of target-focused compound libraries.

The design and application of target-focused compound libraries.

http://www.wikidata.org/entity/Q33882226

about

Synthetic biology for pharmaceutical drug discovery Computational methods in drug discovery Antimalarial drug discovery - approaches and progress towards new medicines.A graph-based approach to construct target-focused libraries for virtual screening High content screening of a kinase-focused library reveals compounds broadly-active against dengue viruses Identification of novel compounds inhibiting chikungunya virus-induced cell death by high throughput screening of a kinase inhibitor library A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors Data-driven approaches used for compound library design, hit triage and bioactivity modeling in high-throughput screening.Composition and applications of focus libraries to phenotypic assays Mining the ChEMBL database: an efficient chemoinformatics workflow for assembling an ion channel-focused screening library Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay.Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions.Antimalarial aminothiazoles and aminopyridines from phenotypic whole-cell screening of a SoftFocus(®) library.Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space.Structure-based virtual screening for drug discovery: principles, applications and recent advances.Drug discovery for human African trypanosomiasis: identification of novel scaffolds by the newly developed HTS SYBR Green assay for Trypanosoma brucei.GAMPMS: Genetic algorithm managed peptide mutant screening.Selecting, Acquiring, and Using Small Molecule Libraries for High-Throughput Screening.Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum.Targeting of AMP-activated protein kinase: prospects for computer-aided drug design.Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies.Congestion game scheduling for virtual drug screening optimization.Computationally driven drug discovery meeting-3 - Verona (Italy): 4 - 6th of March 2014.Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes.Recent updates in the discovery and development of novel antimalarial drug candidates Insights into the development of chemical probes for RNA

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P2860

The design and application of target-focused compound libraries.

http://www.wikidata.org/entity/Q33882226

description

2011 nî lūn-bûn

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2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հուլիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

The design and application of target-focused compound libraries.

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The design and application of target-focused compound libraries.

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The design and application of target-focused compound libraries.

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The design and application of target-focused compound libraries.

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The design and application of target-focused compound libraries.

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Combinatorial Chemistry & High Throughput Screening

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The design and application of target-focused compound libraries.

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C John Harris

http://www.w3.org/2001/XMLSchema#string

David W Sheppard

http://www.w3.org/2001/XMLSchema#string

Martin J Slater

http://www.w3.org/2001/XMLSchema#string

Pieter F W Stouten

http://www.w3.org/2001/XMLSchema#string

Richard D Hill

http://www.w3.org/2001/XMLSchema#string

P2860

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

Selective inhibition of BET bromodomains

Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity

Structure-guided discovery of cyclin-dependent kinase inhibitors

Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design

Achieving structural diversity using the perpendicular conformation of alpha-substituted phenylcyclopropanes to mimic the bioactive conformation of ortho-substituted biphenyl P4 moieties: discovery of novel, highly potent inhibitors of Factor Xa

Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode

High-throughput screening to identify inhibitors which stabilize inactive kinase conformations in p38alpha

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

Ligand efficiency: a useful metric for lead selection

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10.2174/138620711795767802

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