Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway - Wikidata - wikimedia - TriplyDB

Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway

Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway

http://www.wikidata.org/entity/Q33885108

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The TWEAK receptor Fn14 is a potential cell surface portal for targeted delivery of glioblastoma therapeutics TWEAK and the progression of renal disease: clinical translation Soluble Fn14 Is Detected and Elevated in Mouse and Human Kidney Disease Crystal Structure of Human TWEAK in Complex with the Fab Fragment of a Neutralizing Antibody Reveals Insights into Receptor Binding A Bioinformatics Resource for TWEAK-Fn14 Signaling Pathway The relationship between asymptomatic organ damage, and serum soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and Interleukin-17A (IL-17A) levels in non-diabetic hypertensive patients PGC1α plays a critical role in TWEAK-induced cardiac dysfunction.TWEAK-independent Fn14 self-association and NF-κB activation is mediated by the C-terminal region of the Fn14 cytoplasmic domain Development of human serine protease-based therapeutics targeting Fn14 and identification of Fn14 as a new target overexpressed in TNBC.Structural basis and targeting of the interaction between fibroblast growth factor-inducible 14 and tumor necrosis factor-like weak inducer of apoptosis TWEAK-Fn14 as a mediator of acute kidney injury.A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage HIV-1/HAART-Related Lipodystrophy Syndrome (HALS) Is Associated with Decreased Circulating sTWEAK Levels.Identification of aurintricarboxylic acid as a selective inhibitor of the TWEAK-Fn14 signaling pathway in glioblastoma cells The TWEAK receptor Fn14 is a therapeutic target in melanoma: immunotoxins targeting Fn14 receptor for malignant melanoma treatment Antibody deficiency associated with an inherited autosomal dominant mutation in TWEAK.The HER2- and heregulin β1 (HRG)-inducible TNFR superfamily member Fn14 promotes HRG-driven breast cancer cell migration, invasion, and MMP9 expression.CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury The role of soluble tumor necrosis factor like weak inducer of apoptosis and interleukin-17A in the etiopathogenesis of celiac disease: A cross-sectional study.Nuclear Factor κB is Required for Tumor Growth Inhibition Mediated by Enavatuzumab (PDL192), a Humanized Monoclonal Antibody to TweakR.TWEAK/Fn14 Axis: A Promising Target for the Treatment of Cardiovascular Diseases.TWEAK activation of the non-canonical NF-κB signaling pathway differentially regulates melanoma and prostate cancer cell invasion.Thrombospondin-4, tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14: novel extracellular matrix modulating factors in cardiac remodelling.The TWEAK/Fn14 pathway as an aggravating and perpetuating factor in inflammatory diseases: focus on inflammatory bowel diseases.TWEAK: A New Player in Obesity and Diabetes.TWEAK/Fn14 signaling in tumors.TWEAK prevents TNF-α-induced insulin resistance through PP2A activation in human adipocytes.TNF Receptor-Associated Factor 1 is a Major Target of Soluble TWEAK.A homogeneous HTRF assay for the identification of inhibitors of the TWEAK-Fn14 protein interaction.TWEAK/Fn14 Axis-Targeted Therapeutics: Moving Basic Science Discoveries to the Clinic.Role of the tumour necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) axis in autoimmune thyroid disease.TWEAK promotes migration and invasion in MEFs through a mechanism dependent on ERKs activation and Fibulin 3 down-regulation.TWEAK binds FN14 Fn14 hepatic progenitor cells are associated with liver fibrosis in biliary atresia.Clinical significance of serum interleukin-8 and soluble tumor necrosis factor-like weak inducer of apoptosis levels in patients with diabetic nephropathy.Are sTWEAK and IL-17A Levels in Inflammatory Bowel Disease Associated with Disease Activity and Etiopathogenesis?

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P2860

Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway

http://www.wikidata.org/entity/Q33885108

description

2010 nî lūn-bûn

@nan

2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年学术文章

@wuu

2010年学术文章

@zh-cn

2010年学术文章

@zh-hans

2010年学术文章

@zh-my

2010年学术文章

@zh-sg

2010年學術文章

@yue

name

Full-length, membrane-anchored ...... activate the NF-kappaB pathway

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Full-length, membrane-anchored ...... activate the NF-kappaB pathway

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type

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Full-length, membrane-anchored ...... activate the NF-kappaB pathway

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Full-length, membrane-anchored ...... activate the NF-kappaB pathway

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prefLabel

Full-length, membrane-anchored ...... activate the NF-kappaB pathway

@ast

Full-length, membrane-anchored ...... activate the NF-kappaB pathway

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P1433

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P356

JBC.M110.131979

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Journal of Biological Chemistry

P1476

Full-length, membrane-anchored ...... activate the NF-kappaB pathway

@en

P2093

Arundhati Ghosh

http://www.w3.org/2001/XMLSchema#string

Jeffrey A Winkles

http://www.w3.org/2001/XMLSchema#string

Sharron A N Brown

http://www.w3.org/2001/XMLSchema#string

P2860

BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth

Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160

A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase

An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein

Mutations within a furin consensus sequence block proteolytic release of ectodysplasin-A and cause X-linked hypohidrotic ectodermal dysplasia

Furin at the cutting edge: from protein traffic to embryogenesis and disease

The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas

The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games

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17432-17441

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scholarly article

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10.1074/JBC.M110.131979

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23

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285

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2010-04-12T00:00:00Z

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20385556

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2878507

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