Conformation of microtubule-bound paclitaxel determined by fluorescence spectroscopy and REDOR NMR.
about
The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic densityA natural love of natural products.Mechanisms of Taxol resistance related to microtubules.Distinct pose of discodermolide in taxol binding pocket drives a complementary mode of microtubule stabilization.Rotational-echo double-resonance NMR distance measurements for the tubulin-bound Paclitaxel conformationThe quest for a simple bioactive analog of paclitaxel as a potential anticancer agent.Drug discovery targeting cell division proteins, microtubules and FtsZ.Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation.Recent advances in the study of the bioactive conformation of taxolUnderstanding tubulin-Taxol interactions: mutations that impart Taxol binding to yeast tubulin.Use of fluorine in the medicinal chemistry and chemical biology of bioactive compounds--a case study on fluorinated taxane anticancer agents.The bioactive Taxol conformation on beta-tubulin: experimental evidence from highly active constrained analogs.The shape of things to come: structural and synthetic studies of taxol and related compoundsAnticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents.Bridging converts a noncytotoxic nor-paclitaxel derivative to a cytotoxic analogue by constraining it to the T-Taxol conformation.Dissecting paclitaxel-microtubule association: quantitative assessment of the 2'-OH groupEvaluation of the tubulin-bound paclitaxel conformation: synthesis, biology, and SAR studies of C-4 to C-3' bridged paclitaxel analoguesExploration of fluorine chemistry at the multidisciplinary interface of chemistry and biology.Design, synthesis, and biological evaluation of novel C14-C3'BzN-linked macrocyclic taxoids.Recent advances in the chemistry and biology of new generation taxoids.Synthesis of isotopically labeled epothilones.Structural studies of taxol analogues for drug discovery.The Application of REDOR NMR to Understand the Conformation of Epothilone B.Structural biology of supramolecular assemblies by magic-angle spinning NMR spectroscopy.Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation.Design, synthesis and biological evaluation of a simplified fluorescently labeled discodermolide as a molecular probe to study the binding of discodermolide to tubulin.Synthesis and bioactivity of a side chain bridged paclitaxel: A test of the T-Taxol conformation.REDOR NMR for drug discovery.Paclitaxel-induced microtubule stabilization causes mitotic block and apoptotic-like cell death in a paclitaxel-sensitive strain of Saccharomyces cerevisiae.The paclitaxel site in tubulin probed by site-directed mutagenesis of Saccharomyces cerevisiae beta-tubulinA model of reversible inhibitors in the gastric H+/K+-ATPase binding site determined by rotational echo double resonance NMR.Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery.
P2860
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P2860
Conformation of microtubule-bound paclitaxel determined by fluorescence spectroscopy and REDOR NMR.
description
2000 nî lūn-bûn
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2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունվարին հրատարակված գիտական հոդված
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2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Conformation of microtubule-bo ...... ce spectroscopy and REDOR NMR.
@ast
Conformation of microtubule-bo ...... ce spectroscopy and REDOR NMR.
@en
type
label
Conformation of microtubule-bo ...... ce spectroscopy and REDOR NMR.
@ast
Conformation of microtubule-bo ...... ce spectroscopy and REDOR NMR.
@en
prefLabel
Conformation of microtubule-bo ...... ce spectroscopy and REDOR NMR.
@ast
Conformation of microtubule-bo ...... ce spectroscopy and REDOR NMR.
@en
P2093
P356
P1433
P1476
Conformation of microtubule-bo ...... ce spectroscopy and REDOR NMR.
@en
P2093
Gryczynski Z
Kingston DG
Piszczek G
Schaefer J
Studelska DR
P304
P356
10.1021/BI991936R
P407
P577
2000-01-01T00:00:00Z