Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation.
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Taccalonolide microtubule stabilizersStructural basis of microtubule stabilization by laulimalide and peloruside AZampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubulesIn vitro and in vivo therapeutic approach for a small cell carcinoma of the ovary hypercalcaemic type using a SCCOHT-1 cellular model.A phase 2 study of epothilone B analog BMS-247550 (NSC 710428) in patients with relapsed aggressive non-Hodgkin lymphomasMutations in the β-tubulin binding site for peloruside A confer resistance by targeting a cleft significant in side chain binding.Structural elements of an NRPS cyclization domain and its intermodule docking domain.Altered TUBB3 expression contributes to the epothilone response of mitotic cells.Locoregional interaction of ixabepilone (ixempra) after breast cancer radiation.Breast Cancer Cell Lines Exhibit Differential Sensitivities to Microtubule-targeting Drugs Independent of Doubling Time.Chemically diverse microtubule stabilizing agents initiate distinct mitotic defects and dysregulated expression of key mitotic kinasesStructural evidence for cooperative microtubule stabilization by Taxol and the endogenous dynamics regulator MAP4.2-(m-Azidobenzoyl)taxol binds differentially to distinct β-tubulin isotypesTaccalonolide binding to tubulin imparts microtubule stability and potent in vivo activity.Total synthesis of (-)-18-epi-peloruside A: an alkyne linchpin strategy.Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM StructuresPeloruside, laulimalide, and noscapine interactions with beta-tubulin.Tubulin inhibitors: a patent review.Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities.Synthetic, semisynthetic and natural analogues of peloruside A.Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration.Peloruside A: a lead non-taxoid-site microtubule-stabilizing agent with potential activity against cancer, neurodegeneration, and autoimmune disease.Reversal of human multi-drug resistance leukaemic cells by stemofoline derivatives via inhibition of P-glycoprotein function.Characterizing the laulimalide-peloruside binding site using site-directed mutagenesis of TUB2 in S. cerevisiae.Taxol®: The First Microtubule Stabilizing Agent.Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: implications for chemotherapy-induced peripheral neuropathy.Axonal Transport Impairment in Chemotherapy-Induced Peripheral NeuropathyMechanical and functional properties of epothilone-stabilized microtubules.
P2860
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P2860
Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Hallmarks of molecular action ...... e on microtubule conformation.
@ast
Hallmarks of molecular action ...... e on microtubule conformation.
@en
Hallmarks of molecular action ...... e on microtubule conformation.
@nl
type
label
Hallmarks of molecular action ...... e on microtubule conformation.
@ast
Hallmarks of molecular action ...... e on microtubule conformation.
@en
Hallmarks of molecular action ...... e on microtubule conformation.
@nl
prefLabel
Hallmarks of molecular action ...... e on microtubule conformation.
@ast
Hallmarks of molecular action ...... e on microtubule conformation.
@en
Hallmarks of molecular action ...... e on microtubule conformation.
@nl
P2093
P2860
P356
P1476
Hallmarks of molecular action ...... e on microtubule conformation.
@en
P2093
Chia-Ping Huang Yang
John H Miller
Marina Khrapunovich-Baine
Peter T Northcote
Ruth Hogue Angeletti
Vilas Menon
P2860
P304
11765-11778
P356
10.1074/JBC.M110.162214
P407
P577
2011-01-18T00:00:00Z