The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic beta-cells: action of synaptotagmin at low micromolar calcium.
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Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII)Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cellsRole of the conserved WHXL motif in the C terminus of synaptotagmin in synaptic vesicle dockingThe functional significance of synaptotagmin diversity in neuroendocrine secretionSynaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic β-cellsAlternative splicing of synaptotagmins involving transmembrane exon skippingA plethora of presynaptic proteins associated with ATP-storing organelles in cultured astrocytesSynaptotagmin IX regulates Ca2+-dependent secretion in PC12 cellsSynaptotagmin VII regulates Ca(2+)-dependent exocytosis of lysosomes in fibroblastsRNA interference-mediated silencing of synaptotagmin IX, but not synaptotagmin I, inhibits dense-core vesicle exocytosis in PC12 cellsA novel alternatively spliced variant of synaptotagmin VI lacking a transmembrane domain. Implications for distinct functions of the two isoformsConserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and XMechanisms of exocytosis in insulin-secreting B-cells and glucagon-secreting A-cells.Gene expression profiles in rat mesenteric lymph nodes upon supplementation with conjugated linoleic acid during gestation and sucklingCa2+-independent insulin exocytosis induced by alpha-latrotoxin requires latrophilin, a G protein-coupled receptorCa2+-induced exocytosis in individual human neutrophils: high- and low-affinity granule populations and submaximal responses.Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis.Cysteine string protein interacts with and modulates the maturation of the cystic fibrosis transmembrane conductance regulator.GABA in the endocrine pancreas: its putative role as an islet cell paracrine-signalling molecule.The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic beta cells is mediated by a 65-kDa mdr-like P-glycoproteinProtein kinase activation increases insulin secretion by sensitizing the secretory machinery to Ca2+.The mast cell: where endocytosis and regulated exocytosis meet.Synaptotagmins bind calcium to release insulin.Insulin granule biogenesis, trafficking and exocytosis.Altered microRNA and gene expression in the follicular fluid of women with polycystic ovary syndromeThe C2A domain of synaptotagmin-like protein 3 (Slp3) is an atypical calcium-dependent phospholipid-binding machine: comparison with the C2A domain of synaptotagmin I.Vesicle-associated membrane protein-2/synaptobrevin binding to synaptotagmin I promotes O-glycosylation of synaptotagmin I.Formation of crystalloid endoplasmic reticulum induced by expression of synaptotagmin lacking the conserved WHXL motif in the C terminus. Structural importance of the WHXL motif in the C2B domain.Alpha-latrotoxin induces exocytosis by inhibition of voltage-dependent K+ channels and by stimulation of L-type Ca2+ channels via latrophilin in beta-cells.Sorting and storage during secretory granule biogenesis: looking backward and looking forward.Nutrient stimulation results in a rapid Ca2+-dependent threonine phosphorylation of myosin heavy chain in rat pancreatic islets and RINm5F cells.Transient expression of botulinum neurotoxin C1 light chain differentially inhibits calcium and glucose induced insulin secretion in clonal beta-cells.Distinct roles of the C2A and the C2B domain of the vesicular Ca2+ sensor synaptotagmin 9 in endocrine beta-cells.Triggered Ca2+ influx is required for extended synaptotagmin 1-induced ER-plasma membrane tethering.Regulation of CFTR trafficking by its R domain.The C2A domain of synaptotagmin alters the kinetics of voltage-gated Ca2+ channels Ca(v)1.2 (Lc-type) and Ca(v)2.3 (R-type).Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions.Evolutionary origin of synapses and neurons - Bridging the gap.Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.Nerve growth factor-dependent sorting of synaptotagmin IV protein to mature dense-core vesicles that undergo calcium-dependent exocytosis in PC12 cells.
P2860
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P2860
The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic beta-cells: action of synaptotagmin at low micromolar calcium.
description
1997 nî lūn-bûn
@nan
1997 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
The first C2 domain of synapto ...... min at low micromolar calcium.
@ast
The first C2 domain of synapto ...... min at low micromolar calcium.
@en
type
label
The first C2 domain of synapto ...... min at low micromolar calcium.
@ast
The first C2 domain of synapto ...... min at low micromolar calcium.
@en
prefLabel
The first C2 domain of synapto ...... min at low micromolar calcium.
@ast
The first C2 domain of synapto ...... min at low micromolar calcium.
@en
P2093
P2860
P356
P1433
P1476
The first C2 domain of synapto ...... gmin at low micromolar calcium
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/16.19.5837
P407
P577
1997-10-01T00:00:00Z