Protein kinase activation increases insulin secretion by sensitizing the secretory machinery to Ca2+. - Wikidata - wikimedia - TriplyDB

Protein kinase activation increases insulin secretion by sensitizing the secretory machinery to Ca2+.

Protein kinase activation increases insulin secretion by sensitizing the secretory machinery to Ca2+.

http://www.wikidata.org/entity/Q36445740

about

TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells Mechanisms of action of glucagon-like peptide 1 in the pancreas Pancreatic regulation of glucose homeostasis Cyclic AMP dynamics in the pancreatic β-cell Insulin secretion: a high-affinity Ca2+ sensor after all?Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants Exocytosis, Endocytosis, and Their Coupling in Excitable Cells.PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.Cyclic AMP potentiates Ca2+-dependent exocytosis in pancreatic duct epithelial cells.Possible protective effect of membrane lipid rafts against interleukin-1β-mediated anti-proliferative effect in INS-1 cells.Lessons from models of pancreatic beta cells for engineering glucose-sensing cells Contribution of protein kinase Cα in the stimulation of insulin by the down-regulation of Cavβ subunits.Activators of PKA and Epac distinctly influence insulin secretion and cytosolic Ca2+ in female mouse islets stimulated by glucose and tolbutamide.Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans Munc18-1 and Munc18-2 proteins modulate beta-cell Ca2+ sensitivity and kinetics of insulin exocytosis differently.Evolving insights regarding mechanisms for the inhibition of insulin release by norepinephrine and heterotrimeric G proteins.Phosphomimetic mutation of Ser-187 of SNAP-25 increases both syntaxin binding and highly Ca2+-sensitive exocytosis.Ca2+-secretion coupling is impaired in diabetic Goto Kakizaki rats PKC-induced sensitization of Ca2+-dependent exocytosis is mediated by reducing the Ca2+ cooperativity in pituitary gonadotropes.A highly Ca2+-sensitive pool of granules is regulated by glucose and protein kinases in insulin-secreting INS-1 cells Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets.Newcomer insulin secretory granules as a highly calcium-sensitive pool GnRH-Induced Ca(2+) Signaling Patterns and Gonadotropin Secretion in Pituitary Gonadotrophs. Functional Adaptations to Both Ordinary and Extraordinary Physiological Demands.Long-term exposure to genistein improves insulin secretory function of pancreatic beta-cells.Contributions of mathematical modeling of beta cells to the understanding of beta-cell oscillations and insulin secretion Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells.Modes of exocytosis and electrogenesis underlying canine biphasic insulin secretion.Excitable Astrocytes: Ca(2+)- and cAMP-Regulated Exocytosis.On depolarization-evoked exocytosis as a function of calcium entry: possibilities and pitfalls.Exocytosis in non-neuronal cells.Free Fatty Acid Receptor 1 (FFAR1) as an Emerging Therapeutic Target for Type 2 Diabetes Mellitus: Recent Progress and Prevailing Challenges.cAMP signalling in insulin and glucagon secretion.Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM.Short-term potentiation of membrane resealing in neighboring cells is mediated by purinergic signaling.Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM.Mathematical modeling of insulin secretion and the role of glucose-dependent mobilization, docking, priming and fusion of insulin granules.A subcellular model of glucose-stimulated pancreatic insulin secretion.Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic beta cells.

P2860

Q24321979-CA8225CF-CCCD-4BDF-9867-EDE28069406E Q24683764-ED70B5B8-B265-4AE4-9D50-FE27EEEDFC02 Q26766485-B1272F9F-2D84-4BC6-9677-58C1CEDEAE72 Q27008275-3DCF8178-22FA-4EB2-B2F5-162AEF33205F Q27863800-9CB3DDCF-3B95-4E1B-BD98-0531548B0F49 Q28249275-6C38F33C-E475-421B-B3F2-A440C333AAFE Q33575912-DE4420F4-D16C-4C9C-8DDE-0D640C75D761 Q33727405-BF89E2BC-C37D-4947-ACAA-FFE8B7F1ECCB Q33814299-92F4A74B-37EE-4CE5-AF62-F8FB47C0EE5B Q33960501-D3C5C061-9D80-4364-9317-A47BA1E6B813 Q34054232-A4D77063-BFA5-4C6C-9B7A-2782C89296BC Q34250802-47513AE9-2F19-41D4-B634-F214F1E22EC4 Q34628129-616CAEDB-8F50-4A3F-BFAF-4C6A9E814199 Q35050470-F0F9A867-D705-4D3E-8E79-097CFA1FCE46 Q35150073-F8936B17-2E70-46D4-A47E-65A310399D8F Q36041923-DF208C7F-447B-43FA-8105-631755969DDD Q36295988-7B4FE0A7-7E93-4257-8345-11C84DC77109 Q36296022-68749D7A-E90E-4C1E-A47A-6164CFCB98FC Q36445703-46F44608-896F-46BE-A4B8-883AED80FAAB Q36445735-8CAD5DA5-8C88-4578-89FB-9A0D9CF28123 Q36543708-B1E8A05A-782A-428B-B4ED-D9A6F3C0B259 Q37039735-CA5EA5AE-FFCA-41DF-ADC6-8D12AB57DBA5 Q37182979-36932356-E15F-49B1-8545-5FF5161251C8 Q37205553-D6B71EE2-1B79-4727-9488-0A0B9DE2605B Q37288088-CFDD5F65-95A6-40B4-A2E3-F794AB195E23 Q37666656-A07ABB09-0D3A-44CB-BFC1-C6AAC9DC6AAA Q37904176-D04578AA-BC8B-467C-898A-BB3784BF3BFD Q37971646-224DD874-8B44-4362-8BC8-EF27D7454A72 Q38366955-D3617616-2EBC-48EE-B67A-92E8B2507568 Q38493134-6F7A76F7-4D64-46B7-9DE9-1D2BE4938D93 Q38759000-8DCABC31-80AD-491B-BA56-C05FE06B7FB5 Q39192856-8DB30635-F3C2-482F-A0AD-51487B3C0936 Q39280145-1364718E-FAA1-4AE7-A3D9-B2BE834115E4 Q39879613-7AF5A641-7374-452D-A50D-753CF02ABAD1 Q40121402-1F8271B8-DADC-4885-98D8-296CE51487A7 Q40196635-2E685641-1970-40D0-BC53-8B71B3745962 Q41846065-CD89660A-1572-4CFB-B008-940449065C5E Q42439349-47C86A64-D6AA-47D1-A516-43DEA56190C7 Q42839735-9E4D9E0A-886E-4660-8D37-50E1EBFEBD27 Q43239185-97D68036-A5AE-4185-9528-EC7F4FDCB345

P2860

Protein kinase activation increases insulin secretion by sensitizing the secretory machinery to Ca2+.

http://www.wikidata.org/entity/Q36445740

description

2004 nî lūn-bûn

@nan

2004年の論文

@ja

2004年学术文章

@wuu

2004年学术文章

@zh-cn

2004年学术文章

@zh-hans

2004年学术文章

@zh-my

2004年学术文章

@zh-sg

2004年學術文章

@yue

2004年學術文章

@zh

2004年學術文章

@zh-hant

name

Protein kinase activation incr ...... e secretory machinery to Ca2+.

@ast

Protein kinase activation incr ...... e secretory machinery to Ca2+.

@en

type

label

Protein kinase activation incr ...... e secretory machinery to Ca2+.

@ast

Protein kinase activation incr ...... e secretory machinery to Ca2+.

@en

prefLabel

Protein kinase activation incr ...... e secretory machinery to Ca2+.

@ast

Protein kinase activation incr ...... e secretory machinery to Ca2+.

@en

P1433

Q36445740-E587C687-0044-4BBD-9F18-564D4EE79E55

P1476

Q36445740-A5CF5BF7-CEEA-4144-BD77-D63A276ABC92

P2093

Q36445740-3ADB49D0-880D-4BC2-80E5-2609C1765555

Q36445740-6FD3AFBF-46D0-4C91-8B21-DC9BB28EEEC7

Q36445740-7186B1BF-7182-4AFC-875A-329F19E8AA2E

Q36445740-8100DD48-F72A-4437-B6E4-4ED9D65E5633

Q36445740-88B8C7FC-2622-44AE-97F2-BB109A4C9154

Q36445740-E901C499-0898-49C5-A8BB-404321F330CD

P2860

Q36445740-1B966FAB-EBCF-48CE-BA34-A8345473348D

Q36445740-1F1C87EB-0E9B-47EB-AC65-FE378F7A6EFA

Q36445740-1F44DE96-F3A3-47D4-B56D-B5B765B20437

Q36445740-1FD3952B-5824-49F9-945D-C156018FF63B

Q36445740-36CB97BA-5814-4BAD-9C96-785CEF7B98A7

Q36445740-4105E24D-511C-48B7-A49D-2932007B3E0F

Q36445740-41A986F2-2007-4904-87FB-22B992DD5608

Q36445740-530DA0D5-4F46-4FB7-B510-C9C778923E65

Q36445740-54D3221A-99CA-404C-97A3-0F965A17C9A5

Q36445740-76FF80C9-C25F-445C-BEF1-87D1873DBDC7

P304

Q36445740-CE2F6254-E1A7-4C73-84B3-175B1594DB3D

P31

Q36445740-CBC7F43E-2628-4D28-B121-1453E9875909

P356

Q36445740-C188411B-88ED-4CFB-A60A-849E949378D4

P433

Q36445740-45E7F029-FFEA-419B-AC94-28AD0F44266F

P478

Q36445740-F220B3DF-C0FD-4C91-9F9E-31F82A720879

P577

Q36445740-F48A0249-D530-4FE2-9405-ACA04B1AF479

P5875

Q36445740-2D0EE8E2-F2AC-4ADC-AD12-58CC7D49AFE5

P698

Q36445740-49AB996D-EA24-4D3E-8AB0-A0F54C89EF69

P921

Q36445740-78F4307F-5D07-4AFA-A95F-10FFDE1C0888

P932

Q36445740-5CDC3E0B-B528-49EF-8E3A-62467CC310FF

P356

P1433

The Journal of General Physiology

P1476

Protein kinase activation incr ...... e secretory machinery to Ca2+.

@en

P2093

Hua Yang

http://www.w3.org/2001/XMLSchema#string

Jiuping Ding

http://www.w3.org/2001/XMLSchema#string

Qun-Fang Wan

http://www.w3.org/2001/XMLSchema#string

Tao Xu

http://www.w3.org/2001/XMLSchema#string

Xuelin Lou

http://www.w3.org/2001/XMLSchema#string

Yongming Dong

http://www.w3.org/2001/XMLSchema#string

P2860

Mechanisms of inhibition of insulin release.

Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells

Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells

Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs

Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells

Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells.

Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells.

Pharmacologic modulation of protein kinase C isozymes: the role of RACKs and subcellular localisation.

The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic beta-cells: action of synaptotagmin at low micromolar calcium.

The SNARE protein SNAP-25 is linked to fast calcium triggering of exocytosis

P304

653-662

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1085/JGP.200409082

http://www.w3.org/2001/XMLSchema#string

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

124

http://www.w3.org/2001/XMLSchema#string

P577

2004-12-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

8155914

http://www.w3.org/2001/XMLSchema#string

P698

15572345

http://www.w3.org/2001/XMLSchema#string

P921

P932

2234026

http://www.w3.org/2001/XMLSchema#string