Alternatively spliced insertions in the paired domain restrict the DNA sequence specificity of Pax6 and Pax8.
about
The paired-domain transcription factor Pax8 binds to the upstream enhancer of the rat sodium/iodide symporter gene and participates in both thyroid-specific and cyclic-AMP-dependent transcriptionGene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regionsCrystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA bindingThe Solution Structure of DNA-free Pax-8 Paired Box Domain Accounts for Redox Regulation of Transcriptional Activity in the Pax Protein FamilyFunctional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferationSumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain developmentRBM4 promotes pancreas cell differentiation and insulin expressionThe Optimedin gene is a downstream target of Pax6Novel PAX6 binding sites in the human genome and the role of repetitive elements in the evolution of gene regulation.Positive autoregulation of the transcription factor Pax6 in response to increased levels of either of its major isoforms, Pax6 or Pax6(5a), in cultured cellsThe functional modulation of epigenetic regulators by alternative splicingAn 'environment to nucleus' signaling system operates in B lymphocytes: redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation.Hypoxia inducible factor 1alpha gene (HIF-1alpha) splice variants: potential prognostic biomarkers in breast cancer.Quantitation of PAX6 and PAX6(5a) transcript levels in adult human lens, cornea, and monkey retina.Canonical and alternative transcript expression of PAX6 and CXCR4 in pancreatic cancer.Eyg and Ey Pax proteins act by distinct transcriptional mechanisms in Drosophila development.Pax6 is a human neuroectoderm cell fate determinantPhysiological state co-regulates thousands of mammalian mRNA splicing events at tandem splice sites and alternative exons.Iris hypoplasia in mice that lack the alternatively spliced Pax6(5a) isoform.3T3 cell lines stably expressing Pax6 or Pax6(5a)--a new tool used for identification of common and isoform specific target genesPAX6 downregulates miR-124 expression to promote cell migration during embryonic stem cell differentiation.Pax6 directly down-regulates Pcsk1n expression thereby regulating PC1/3 dependent proinsulin processing.The homeodomain of Eyeless regulates cell growth and antagonizes the paired domain-dependent retinal differentiation functionPax6; a pleiotropic player in development.Pax6 regulates the expression of Dkk3 in murine and human cell lines, and altered responses to Wnt signaling are shown in FlpIn-3T3 cells stably expressing either the Pax6 or the Pax6(5a) isoform.Overexpression of Pax6 in mouse cornea directly alters corneal epithelial cells: changes in immune function, vascularization, and differentiation.My what big eyes you have: how the Drosophila retina grows.The orchestration of mammalian tissue morphogenesis through a series of coherent feed-forward loops.Pax2/5/8 and Pax6 alternative splicing events in basal chordates and vertebrates: a focus on paired box domain.Regulation of gene expression by Pax6 in ocular cells: a case of tissue-preferred expression of crystallins in lens.Identification of an Alternative Splicing Product of the Otx2 Gene Expressed in the Neural Retina and Retinal Pigmented Epithelial CellsFunctional properties of natural human PAX6 and PAX6(5a) mutantsThe Pax gene family: Highlights from cephalopods.The multiassembly problem: reconstructing multiple transcript isoforms from EST fragment mixtures.PAX6 Isoforms, along with Reprogramming Factors, Differentially Regulate the Induction of Cornea-specific GenesLune/eye gone, a Pax-like protein, uses a partial paired domain and a homeodomain for DNA recognition.Effects of elevated Pax6 expression and genetic background on mouse eye development.PAX6 is expressed in pancreatic cancer and actively participates in cancer progression through activation of the MET tyrosine kinase receptor gene.Mutational analysis of the eyeless gene and phenotypic rescue reveal that an intact Eyeless protein is necessary for normal eye and brain development in Drosophila.Dopamine systems in the forebrain.
P2860
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P2860
Alternatively spliced insertions in the paired domain restrict the DNA sequence specificity of Pax6 and Pax8.
description
1997 nî lūn-bûn
@nan
1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Alternatively spliced insertio ...... specificity of Pax6 and Pax8.
@ast
Alternatively spliced insertio ...... specificity of Pax6 and Pax8.
@en
type
label
Alternatively spliced insertio ...... specificity of Pax6 and Pax8.
@ast
Alternatively spliced insertio ...... specificity of Pax6 and Pax8.
@en
prefLabel
Alternatively spliced insertio ...... specificity of Pax6 and Pax8.
@ast
Alternatively spliced insertio ...... specificity of Pax6 and Pax8.
@en
P2860
P356
P1433
P1476
Alternatively spliced insertio ...... specificity of Pax6 and Pax8.
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/16.22.6793
P407
P577
1997-11-01T00:00:00Z