Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation. - Wikidata - wikimedia - TriplyDB

Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation.

Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation.

http://www.wikidata.org/entity/Q33889357

about

Endoplasmic reticulum stress and type 2 diabetes A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes.Atorvastatin helps preserve pancreatic β cell function in obese C57BL/6 J mice and the effect is related to increased pancreas proliferation and amelioration of endoplasmic-reticulum stress.Valproate pretreatment protects pancreatic β-cells from palmitate-induced ER stress and apoptosis by inhibiting glycogen synthase kinase-3β JNK3 maintains expression of the insulin receptor substrate 2 (IRS2) in insulin-secreting cells: functional consequences for insulin signaling.Murine animal models for preclinical islet transplantation: No model fits all (research purposes).Progression from high insulin resistance to type 2 diabetes does not entail additional visceral adipose tissue inflammation.Therapeutic Approaches for Preserving or Restoring Pancreatic β-Cell Function and Mass.Chronic glucolipotoxic conditions in pancreatic islets impair insulin secretion due to dysregulated calcium dynamics, glucose responsiveness and mitochondrial activity.PPARδ Activation Rescues Pancreatic β-Cell Line INS-1E from Palmitate-Induced Endoplasmic Reticulum Stress through Enhanced Fatty Acid Oxidation.Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis.Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetes The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes.Postprandial Dysmetabolism and Oxidative Stress in Type 2 Diabetes: Pathogenetic Mechanisms and Therapeutic Strategies.Interorgan Crosstalk Contributing to β-Cell Dysfunction.Peritoneal dialysis fluid activates calcium signaling and apoptosis in mesothelial cells.ATF3 expression in cardiomyocytes preserves homeostasis in the heart and controls peripheral glucose tolerance.A delayed proinflammatory response of human preadipocytes to PCB126 is dependent on the aryl hydrocarbon receptor.Testing the plasticity of insulin secretion and β-cell functionin vivo: responses to chronic hyperglycaemia in the sheep

P2860

Q26864238-90433368-BC31-422C-B6E4-B08C22CF423C Q33631445-88C3AC9B-C550-4D03-862B-B0C6B7070B89 Q33835644-6C096E04-7059-46B4-BF68-7820F0FEBFC5 Q33854627-E70750EC-1754-408C-989D-EAC5AC935E8F Q34260055-AB475710-D68A-4FA3-B5F5-D15FD210719E Q34375570-2BC98F9E-E67F-4869-824C-F268902607F7 Q34461002-A5EAEDDF-B000-485A-8D4F-057B2E8A6D0F Q34750027-26463F6C-6CC2-4068-A86E-F02F43304FC1 Q34787903-F9DEF5D4-485E-4F03-AD58-E6622F0941E4 Q36072327-8597380A-97AF-440B-B402-AA0DE8D60E4F Q36305288-1DAD1D62-E97D-42E4-A44C-87424D6040E5 Q36561524-4094A0E3-4C63-4E3B-B317-1148387B948C Q36796096-24495A7E-7EF8-433F-BBCD-10EEAE36D702 Q38424338-2B4C5B56-AEA6-410D-A441-F88419B350A6 Q38460480-BC938794-9B91-478E-A978-141257B4C0D6 Q39123515-89CEC8E1-A438-46C1-B35E-334587BE6E89 Q45347759-7341C19E-9BB1-464B-9680-044001156F53 Q51194041-2F6CD9FA-6FB8-48DA-892B-12168EED3F2D Q52682873-F584FEF3-1015-47AD-92D6-4AEAAC3913DF Q57692348-4B5A40AC-93A8-4D06-91CE-E5430FF5AA98

P2860

Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation.

http://www.wikidata.org/entity/Q33889357

description

2011 nî lūn-bûn

@nan

2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Glucose and fatty acids synerg ...... independent of JNK activation.

@ast

Glucose and fatty acids synerg ...... independent of JNK activation.

@en

type

label

Glucose and fatty acids synerg ...... independent of JNK activation.

@ast

Glucose and fatty acids synerg ...... independent of JNK activation.

@en

prefLabel

Glucose and fatty acids synerg ...... independent of JNK activation.

@ast

Glucose and fatty acids synerg ...... independent of JNK activation.

@en

P1433

Q33889357-7713BC20-1246-4F86-9E20-9FB22F8EE539

P1476

Q33889357-E36FCE42-163A-46FF-B5B2-3BC29AFCCCBF

P2093

Q33889357-066E7E88-B8D9-40B8-8697-76F313DEF5F6

Q33889357-06BA8992-7914-422A-95BA-A7DB166DF51E

Q33889357-454EBE04-2975-45E6-B7C3-5923BF6ECA24

Q33889357-59F6F4DA-E839-47A6-9339-655D3BF48278

Q33889357-60021DD5-17DB-4437-AA05-0FF954CF6547

Q33889357-6758DD94-55F2-4E57-B137-E77B5E9A4196

Q33889357-A69AF06D-45FA-4A1D-8D73-DF3332392EB1

Q33889357-CE557144-D311-446D-AFDE-C2D3A58A7EE8

Q33889357-E35149A1-058B-4DE9-AB94-5EC90F2C9A3C

Q33889357-F2A5D959-10FF-4E84-80DC-F4430AD91D11

P2860

Q33889357-0440AF08-A57C-4F16-A0CA-65980D16EA5E

Q33889357-05056CF5-879B-4926-B00D-485D8A4A04CE

Q33889357-0DC9E249-BA6C-4FA4-A0F6-2CBE6D3D18D7

Q33889357-1C421E93-E525-4153-B0EF-6639270E0B0F

Q33889357-1FDF7732-A082-464F-8D9F-F47338C8080C

Q33889357-29897314-AB0C-460C-AF75-DCB117C1E1CD

Q33889357-2C8BD483-4EE2-4B17-BE7A-DB05E9BFEF76

Q33889357-3C8CD461-BB58-4DC8-89AF-0BAE9461DB21

Q33889357-40CB1E76-247D-4516-9DDF-AAD00D8C4625

Q33889357-41815957-599F-40F0-B90B-139757C10790

P304

Q33889357-CB73CE98-013F-4523-87EF-1166024BD52A

P31

Q33889357-7B7E731C-A569-4A2E-AB61-30078C85F3B9

P356

Q33889357-DE9579EB-D3A2-4E0A-87B6-AB82C20D4A8D

P407

Q33889357-A7D57849-7E40-466E-908C-A98773DCEBFE

P433

Q33889357-EC6436D2-7914-415A-B11D-347207B3D24A

P478

Q33889357-70BCA8E9-640C-485B-B4CD-CB5E19A2B60A

P50

Q33889357-66510D51-B17A-4CA7-8ED0-23C44A354AA2

P577

Q33889357-8ECE44A2-E327-4971-BB5A-8839DA80FA80

P5875

Q33889357-F12A0049-7862-4EF4-96F0-F95C70B2BE66

P698

Q33889357-B953F72F-4F51-4CFA-A45B-DCE6531351E2

P921

Q33889357-3AD78AF4-E3B7-4CBD-95ED-D92EB7562FFA

P932

Q33889357-214D9D44-1260-46C9-851C-BD0520C26041

P356

JOURNAL.PONE.0018146

P1433

P1476

Glucose and fatty acids synerg ...... independent of JNK activation.

@en

P2093

Christopher J Rhodes

http://www.w3.org/2001/XMLSchema#string

Cris M Welling

http://www.w3.org/2001/XMLSchema#string

Erik Zmuda

http://www.w3.org/2001/XMLSchema#string

Ernesto Bernal-Mizrachi

http://www.w3.org/2001/XMLSchema#string

Katsuya Tanabe

http://www.w3.org/2001/XMLSchema#string

M Alan Permutt

http://www.w3.org/2001/XMLSchema#string

Nada A Abumrad

http://www.w3.org/2001/XMLSchema#string

Sara C Martinez

http://www.w3.org/2001/XMLSchema#string

Syed D Hasan

http://www.w3.org/2001/XMLSchema#string

Tsonwin Hai

http://www.w3.org/2001/XMLSchema#string

P2860

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element

Multiple metabolic hits converge on CD36 as novel mediator of tubular epithelial apoptosis in diabetic nephropathy

Affordable image analysis using NIH Image/ImageJ

Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1

Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets

Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

Protein sensors for membrane sterols

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

P304

e18146

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1371/JOURNAL.PONE.0018146

http://www.w3.org/2001/XMLSchema#string

P407

P433

4

http://www.w3.org/2001/XMLSchema#string

P478

6

http://www.w3.org/2001/XMLSchema#string

P50

Corentin Cras-Méneur

P577

2011-04-26T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51097120

http://www.w3.org/2001/XMLSchema#string

P698

21541314

http://www.w3.org/2001/XMLSchema#string

P921

P932

3082528

http://www.w3.org/2001/XMLSchema#string