Testing the plasticity of insulin secretion and β-cell functionin vivo: responses to chronic hyperglycaemia in the sheep

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Effect of placental restriction and neonatal exendin-4 treatment on postnatal growth, adult body composition, and in vivo glucose metabolism in the sheep.Small size at birth predicts decreased cardiomyocyte number in the adult ovine heart.

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Q36244471-581269B2-99B9-4F03-8435-77824FE0DF32 Q47184084-15AE1A3B-12AC-4F0B-91C9-26730BBEB867

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Testing the plasticity of insulin secretion and β-cell functionin vivo: responses to chronic hyperglycaemia in the sheep

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http://www.wikidata.org/entity/Q57692348

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article

@en

im März 2012 veröffentlichter wissenschaftlicher Artikel

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wetenschappelijk artikel

@nl

наукова стаття, опублікована в березні 2012

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Testing the plasticity of insu ...... ic hyperglycaemia in the sheep

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Testing the plasticity of insu ...... ic hyperglycaemia in the sheep

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Testing the plasticity of insu ...... ic hyperglycaemia in the sheep

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Testing the plasticity of insu ...... ic hyperglycaemia in the sheep

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Testing the plasticity of insu ...... ic hyperglycaemia in the sheep

@en

Testing the plasticity of insu ...... ic hyperglycaemia in the sheep

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Testing the plasticity of insu ...... ic hyperglycaemia in the sheep

@en

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Brooke L Summers-Pearce

http://www.w3.org/2001/XMLSchema#string

M Lyn Harland

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Tasma A How

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation.

Islet growth and development in the adult.

Glucose infusion in mice: a new model to induce beta-cell replication.

Regulatory effects of glucose on the catalytic activity and cellular content of glucokinase in the pancreatic beta cell. Study using cultured rat islets

Reduced early insulin secretion in the etiology of type 2 diabetes mellitus in Pima Indians.

Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions.

Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications.

Plasticity of the beta cell insulin secretory competence: preparing the pancreatic beta cell for the next meal.

Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes.

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663-675

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scholarly article

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10.1113/EXPPHYSIOL.2011.063560

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http://www.w3.org/2001/XMLSchema#string

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http://www.w3.org/2001/XMLSchema#string

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Julie Owens

Kathryn L Gatford

Miles J De Blasio

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2012-01-27T00:00:00Z

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22286370

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hyperglycemia

Insulin

Testing the plasticity of insulin secretion and β-cell functionin vivo: responses to chronic hyperglycaemia in the sheep

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P2860

P2860

Testing the plasticity of insulin secretion and β-cell functionin vivo: responses to chronic hyperglycaemia in the sheep

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type

label

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P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P698

P921

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P698

P921