The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region.
about
Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brainPro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pHProteolytic processing of Alzheimer's β-amyloid precursor proteinBACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's diseaseBACE1 expression and activity: relevance in Alzheimer's diseaseThe normal and pathologic roles of the Alzheimer's β-secretase, BACE1A tale of two drug targets: the evolutionary history of BACE1 and BACE2Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases.BACE1 and BACE2 enzymatic activities in Alzheimer's disease.Prodomain processing of Asp1 (BACE2) is autocatalytic.BACE1 inhibitory activity of fungal endophytic extracts from Malaysian medicinal plantsExpression of reticulon 3 in Alzheimer's disease brain.Enzymic properties of recombinant BACE2.Secretases as therapeutic targets for the treatment of Alzheimer's disease.Association study of candidate gene polymorphisms with amnestic mild cognitive impairment in a Chinese populationMulberry extracts alleviate aβ 25-35-induced injury and change the gene expression profile in PC12 cells.BACE2 expression increases in human neurodegenerative disease.Future Therapeutics in Alzheimer's Disease: Development Status of BACE Inhibitors.Identification of BACE2 as an avid ß-amyloid-degrading proteaseDown's syndrome, neuroinflammation, and Alzheimer neuropathogenesis.Aspects of beta-amyloid as a biomarker for Alzheimer's disease.Identification and biology of β-secretase.Treatment strategies targeting amyloid β-protein.Recent progress in the drug discovery of non-peptidic BACE1 inhibitors.BACE2 as a new diabetes target: a patent review (2010 - 2012).The FOXP2-Driven Network in Developmental Disorders and NeurodegenerationUpregulation of SET expression by BACE1 and its implications in Down syndrome.BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors.Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation.The protease inhibitor, MG132, blocks maturation of the amyloid precursor protein Swedish mutant preventing cleavage by beta-Secretase.β-Secretase activity in rat astrocytes: translational block of BACE1 and modulation of BACE2 expression.In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase.BACE2 is stored in secretory granules of mouse and rat pancreatic beta cells.BACE2 degradation mediated by the macroautophagy-lysosome pathway.Amyloid precursor protein beta-secretase (BACE) mRNA expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines and growth factors.
P2860
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P2860
The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region.
description
2000 nî lūn-bûn
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2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
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2000年論文
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2000年论文
@wuu
name
The gene encoding DRAP (BACE2) ...... s to the down critical region.
@ast
The gene encoding DRAP (BACE2) ...... s to the down critical region.
@en
type
label
The gene encoding DRAP (BACE2) ...... s to the down critical region.
@ast
The gene encoding DRAP (BACE2) ...... s to the down critical region.
@en
prefLabel
The gene encoding DRAP (BACE2) ...... s to the down critical region.
@ast
The gene encoding DRAP (BACE2) ...... s to the down critical region.
@en
P2093
P2860
P1433
P1476
The gene encoding DRAP (BACE2) ...... s to the down critical region.
@en
P2093
Accarino M
Fumagalli P
Ottolenghi S
Taramelli R
P2860
P356
10.1016/S0014-5793(00)01192-3
P407
P50
P577
2000-02-01T00:00:00Z