Disease states associated with telomerase deficiency appear earlier in mice with short telomeres - Wikidata - wikimedia - TriplyDB

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

http://www.wikidata.org/entity/Q33890968

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Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres.Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.Allosteric inhibitors of telomerase: oligonucleotide N3'-->P5' phosphoramidates Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer The telomere syndromes The differentiation status of primary gonadal germ cell tumors correlates inversely with telomerase activity and the expression level of the gene encoding the catalytic subunit of telomerase Role of Telomerase in the Cardiovascular System Telomere regulation in pluripotent stem cells BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo Ageing and telomeres: a study into organ- and gender-specific telomere shortening 'Accelerated aging': a primrose path to insight?Variation at the TERT locus and predisposition for cancer Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites mRNA decay factor AUF1 maintains normal aging, telomere maintenance, and suppression of senescence by activation of telomerase transcription Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing Opposing impacts on healthspan and longevity by limiting dietary selenium in telomere dysfunctional mice Advances in the understanding of dyskeratosis congenita A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity Telomere Length Maintenance and Cardio-Metabolic Disease Prevention Through Exercise Training.Responses to telomere erosion in plants.TopoIIα prevents telomere fragility and formation of ultra thin DNA bridges during mitosis through TRF1-dependent binding to telomeres Abnormal telomere metabolism in Fanconi's anaemia correlates with genomic instability and the probability of developing severe aplastic anaemia.Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.Telomere attrition due to infection.A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis.A p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres.Telomere recombination accelerates cellular aging in Saccharomyces cerevisiae FANCC suppresses short telomere-initiated telomere sister chromatid exchange Telomere length, aging, and somatic cell turnover.ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase.Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang.Requirement of functional telomeres for metaphase chromosome alignments and integrity of meiotic spindles.Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres.An increase in telomere sister chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres.Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging.Cell senescence and cancer.

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Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

http://www.wikidata.org/entity/Q33890968

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1999 nî lūn-bûn

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1999 թուականի Յունիսին հրատարակուած գիտական յօդուած

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1999年の論文

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The EMBO Journal

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Blasco MA

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Flores JM

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Herrera E

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Lee HW

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Martín-Caballero J

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Samper E

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P2860

The telomerase reverse transcriptase: components and regulation

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

Extension of life-span by introduction of telomerase into normal human cells

Human telomerase contains evolutionarily conserved catalytic and structural subunits

The RNA component of human telomerase

Telomere length regulation

Myc activates telomerase

TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family

A mammalian telomerase-associated protein

Telomeres shorten during ageing of human fibroblasts

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2950-2960

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10357808

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1171377

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