Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole.
about
Macrocyclic histone deacetylase inhibitorsChemical phylogenetics of histone deacetylases.Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides.Vorinostat-like molecules as structural, stereochemical, and pharmacological toolsBiological evaluation of new largazole analogues: alteration of macrocyclic scaffold with click chemistry.Potent and orally efficacious bisthiazole-based histone deacetylase inhibitorsEvaluation of class I HDAC isoform selectivity of largazole analoguesInhibition and mechanism of HDAC8 revisited.Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groupsComputational exploration of zinc binding groups for HDAC inhibitionIn Vitro and In Vivo Osteogenic Activity of Largazole.Comparative pharmacokinetic properties and antitumor activity of the marine HDACi Largazole and Largazole peptide isostereNatural products synthesis: enabling tools to penetrate Nature's secrets of biogenesis and biomechanism.Variable active site loop conformations accommodate the binding of macrocyclic largazole analogues to HDAC8Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole.FK228 Analogues Induce Fetal Hemoglobin in Human Erythroid Progenitors.Largazole: from discovery to broad-spectrum therapy.Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffoldDiscovery and mechanism of natural products as modulators of histone acetylation.Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs.Probing the biology of natural products: molecular editing by diverted total synthesis.Thiazole and oxazole alkaloids: isolation and synthesis.Targeting epigenetics through histone deacetylase inhibitors in acute lymphoblastic leukemia.Microbial natural products: molecular blueprints for antitumor drugs.Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation.Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes.Selective histone deacetylase small molecule inhibitors: recent progress and perspectives.Total syntheses of the histone deacetylase inhibitors largazole and 2-epi-largazole: application of N-heterocyclic carbene mediated acylations in complex molecule synthesis.Discovery of HDAC Inhibitors That Lack an Active Site Zn(2+)-Binding Functional Group.Synthesis and biological evaluation of c7-demethyl largazole analogues.Microwave-assisted synthesis and antitumor evaluation of a new series of thiazolylcoumarin derivatives.Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure-Activity Relationships.Synthesis and Evaluation of Thiazolidine Amide and N-Thiazolyl Amide Fluoroquinolone Derivatives.Total synthesis of (18S)- and (18R)-homolargazole by rhodium-catalyzed hydrocarboxylation.
P2860
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P2860
Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole.
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Synthesis and conformation-act ...... steres of FK228 and largazole.
@ast
Synthesis and conformation-act ...... steres of FK228 and largazole.
@en
type
label
Synthesis and conformation-act ...... steres of FK228 and largazole.
@ast
Synthesis and conformation-act ...... steres of FK228 and largazole.
@en
prefLabel
Synthesis and conformation-act ...... steres of FK228 and largazole.
@ast
Synthesis and conformation-act ...... steres of FK228 and largazole.
@en
P2093
P2860
P356
P1476
Synthesis and conformation-act ...... steres of FK228 and largazole.
@en
P2093
Albert A Bowers
Guillermina Estiu
James E Bradner
Nathan West
Olaf Wiest
Robert M Williams
Stuart L Schreiber
Thomas J Greshock
P2860
P304
P356
10.1021/JA807772W
P407
P577
2009-03-01T00:00:00Z