Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding.
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The CK1 Family: Contribution to Cellular Stress Response and Its Role in CarcinogenesisActivation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylationInhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cellsp53 Stabilization and accumulation induced by human vaccinia-related kinase 1HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic functionHIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levelsMapping the interactions of the p53 transactivation domain with the KIX domain of CBPNutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescenceStructural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylationCooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2Structure of the p53 Transactivation Domain in Complex with the Nuclear Receptor Coactivator Binding Domain of CREB Binding Proteinp53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum ConceptPlk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathwayInhibition of p53-dependent transcription by BOX-I phospho-peptide mimetics that bind to p300.Activation and activities of the p53 tumour suppressor proteinSimulating molecular mechanisms of the MDM2-mediated regulatory interactions: a conformational selection model of the MDM2 lid dynamicsExploiting the MDM2-CK1α protein-protein interface to develop novel biologics that induce UBL-kinase-modification and inhibit cell growthStoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription.Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.Zsyntax: a formal language for molecular biology with projected applications in text mining and biological prediction.Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylationPosttranslational modification of p53: cooperative integrators of functionPathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseasesThe human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.Regulation of p53-MDMX interaction by casein kinase 1 alpha.Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitination.Controlling the Mdm2-Mdmx-p53 Circuit.The p53 orchestra: Mdm2 and Mdmx set the toneStrategies for manipulating the p53 pathway in the treatment of human cancer.DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53.Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivoChk2-deficient mice exhibit radioresistance and defective p53-mediated transcriptionBioinformatics study of cancer-related mutations within p53 phosphorylation site motifsMutation of mouse p53 Ser23 and the response to DNA damage.Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation.The central region of HDM2 provides a second binding site for p53.The Epstein-Barr virus immediate-early protein BZLF1 regulates p53 function through multiple mechanismsSustained phosphorylation of Bid is a marker for resistance to Fas-induced apoptosis during chronic liver diseases.
P2860
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P2860
Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding.
description
2000 nî lūn-bûn
@nan
2000 թուականի Մարտին հրատարակուած գիտական յօդուած
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2000 թվականի մարտին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Damage-mediated phosphorylatio ...... inase. Effect on Mdm2 binding.
@ast
Damage-mediated phosphorylatio ...... inase. Effect on Mdm2 binding.
@en
type
label
Damage-mediated phosphorylatio ...... inase. Effect on Mdm2 binding.
@ast
Damage-mediated phosphorylatio ...... inase. Effect on Mdm2 binding.
@en
prefLabel
Damage-mediated phosphorylatio ...... inase. Effect on Mdm2 binding.
@ast
Damage-mediated phosphorylatio ...... inase. Effect on Mdm2 binding.
@en
P2093
P356
P1476
Damage-mediated phosphorylatio ...... inase. Effect on Mdm2 binding.
@en
P2093
P304
P356
10.1074/JBC.275.13.9278
P407
P577
2000-03-01T00:00:00Z