A commentary on the use of hepatocytes in drug metabolism studies during drug discovery and development.
about
The human L-threonine 3-dehydrogenase gene is an expressed pseudogene.Microfabricated mammalian organ systems and their integration into models of whole animals and humansUse of a cocktail of probe substrates for drug-metabolizing enzymes for the assessment of the metabolic capacity of hepatocyte preparations.Summary of information on human CYP enzymes: human P450 metabolism data.Three-dimensional culture of human embryonic stem cell derived hepatic endoderm and its role in bioartificial liver constructionFunctional xenobiotic metabolism and efflux transporters in trout hepatocyte spheroid cultures.Inter-individual variability in levels of human microsomal protein and hepatocellularity per gram of liverCell-based models to study hepatic drug metabolism and enzyme induction in humans.In vitro-in vivo extrapolation of hepatic clearance: biological tools, scaling factors, model assumptions and correct concentrations.Predictive tools for the evaluation of microbial effects on drugs during gastrointestinal passage.Cellular models for disease exploring and drug screeningLiver Cell Culture Devices.Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance.In vitro models of xenobiotic metabolism in trout for use in environmental bioaccumulation studies.Impaired glutathione-conjugating capacity by cryopreserved human and rat hepatocytes.Prediction of hepatic plasma clearance in vivo from gel-entrapped rat and human hepatocytes.Gene expression profiles in rat liver slices exposed to hepatocarcinogenic enzyme inducers, peroxisome proliferators, and 17alpha-ethinylestradiol.Use of hepatocytes isolated from a liver-humanized mouse for studies on the metabolism of drugs: application to the metabolism of fentanyl and acetylfentanyl.
P2860
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P2860
A commentary on the use of hepatocytes in drug metabolism studies during drug discovery and development.
description
2000 nî lūn-bûn
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2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2000 թվականի մայիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
A commentary on the use of hep ...... rug discovery and development.
@ast
A commentary on the use of hep ...... rug discovery and development.
@en
type
label
A commentary on the use of hep ...... rug discovery and development.
@ast
A commentary on the use of hep ...... rug discovery and development.
@en
prefLabel
A commentary on the use of hep ...... rug discovery and development.
@ast
A commentary on the use of hep ...... rug discovery and development.
@en
P2860
P356
P1476
A commentary on the use of hep ...... rug discovery and development.
@en
P2093
P2860
P304
P356
10.1081/DMR-100100574
P407
P577
2000-05-01T00:00:00Z