Interspecies scaling of tolcapone, a new inhibitor of catechol-O-methyltransferase (COMT). Use of in vitro data from hepatocytes to predict metabolic clearance in animals and humans.

Interspecies scaling of tolcapone, a new inhibitor of catechol-O-methyltransferase (COMT). Use of in vitro data from hepatocytes to predict metabolic clearance in animals and humans.

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http://www.wikidata.org/entity/Q36827999
Use of a cocktail of probe substrates for drug-metabolizing enzymes for the assessment of the metabolic capacity of hepatocyte preparations.Prediction of human pharmacokinetics from animal data and molecular structural parameters using multivariate regression analysis: volume of distribution at steady state.A commentary on the use of hepatocytes in drug metabolism studies during drug discovery and development.Prediction of drug concentration-time data in humans from animals: a comparison of three methods.Estimating xenobiotic half-lives in humans from rat data: influence of log P.Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance.Tolcapone, a selective catechol-O-methyltransferase inhibitor for treatment of Parkinson's disease.Interspecies pharmacokinetic comparisons and allometric scaling of napsagatran, a low molecular weight thrombin inhibitor.Interspecies scaling: predicting volumes, mean residence time and elimination half-life. Some suggestions.
P2860

Interspecies scaling of tolcapone, a new inhibitor of catechol-O-methyltransferase (COMT). Use of in vitro data from hepatocytes to predict metabolic clearance in animals and humans.

Item
http://www.wikidata.org/entity/Q36827999
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Interspecies scaling of tolcap ...... earance in animals and humans.
@en
type
label
Interspecies scaling of tolcap ...... earance in animals and humans.
@en
prefLabel
Interspecies scaling of tolcap ...... earance in animals and humans.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P356
P1433
P1476
Interspecies scaling of tolcap ...... earance in animals and humans.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698