Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer disease
about
The 2013 SFRBM discovery award: selected discoveries from the butterfield laboratory of oxidative stress and its sequela in brain in cognitive disorders exemplified by Alzheimer disease and chemotherapy induced cognitive impairmentChronic apocynin treatment attenuates beta amyloid plaque size and microglial number in hAPP(751)(SL) miceLipid peroxidation and its toxicological implicationsRedox proteomics in selected neurodegenerative disorders: from its infancy to future applications.Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell deathPreclinical Alzheimer disease: brain oxidative stress, Abeta peptide and proteomics.Mitochondrial dysfunction and cellular metabolic deficiency in Alzheimer's diseaseElevated 4-hydroxyhexenal in Alzheimer's disease (AD) progressionDNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes.Oxidatively modified nucleic acids in preclinical Alzheimer's disease (PCAD) brain.Biomarkers of lipid peroxidation in Alzheimer disease (AD): an update.The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons.University of Kentucky Sanders-Brown healthy brain aging volunteers: donor characteristics, procedures and neuropathology.Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer's disease.Acrolein Exposure in U.S. Tobacco Smokers and Non-Tobacco Users: NHANES 2005-2006.4-Hydroxyhexenal (HHE) impairs glutamate transport in astrocyte culturesAmyloid-β toxicity and tau hyperphosphorylation are linked via RCAN1 in Alzheimer's disease.4-Hydroxy-2(E)-nonenal (HNE) catabolism and formation of HNE adducts are modulated by β oxidation of fatty acids in the isolated rat heartHigh-fat diet induces changes in adipose tissue trans-4-oxo-2-nonenal and trans-4-hydroxy-2-nonenal levels in a depot-specific manner.Exploring the Effect of Phyllanthus emblica L. on Cognitive Performance, Brain Antioxidant Markers and Acetylcholinesterase Activity in Rats: Promising Natural Gift for the Mitigation of Alzheimer's Disease.Epigenetic changes in the progression of Alzheimer's disease.Nucleic acid oxidation: an early feature of Alzheimer's disease.Protein-conjugated acrolein as a biochemical marker of brain infarction.Dietary lipids and their oxidized products in Alzheimer's disease.Oxidative damage to RNA in aging and neurodegenerative disorders.Overlapped metabolic and therapeutic links between Alzheimer and diabetes.Role of lipid peroxidation-derived α, β-unsaturated aldehydes in vascular dysfunction.Proteolytic degradation of heat shock protein A2 occurs in response to oxidative stress in male germ cells of the mouse.Anthocyanins Protect SK-N-SH Cells Against Acrolein-Induced Toxicity by Preserving the Cellular Redox State.4-Hydroxy-2-nonenal: a critical target in oxidative stress?Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?Guarana (Paullinia cupana Mart.) prevents β-amyloid aggregation, generation of advanced glycation-end products (AGEs), and acrolein-induced cytotoxicity on human neuronal-like cells.4-Hydroxy-trans-2-nonenal (4-HNE) induces neuronal SH-SY5Y cell death via hampering ATP binding at kinase domain of Akt1.Signaling by 4-hydroxy-2-nonenal: Exposure protocols, target selectivity and degradation.4-hydroxynonenal-mediated signaling and aging.Lithium prevents acrolein-induced neurotoxicity in HT22 mouse hippocampal cells.Curcumin protects neuronal-like cells against acrolein by restoring Akt and redox signaling pathways.Acrolein stimulates the synthesis of IL-6 and C-reactive protein (CRP) in thrombosis model mice and cultured cells.4-Oxo-(E)-2-hexenal produced by Heteroptera induces permanent locomotive impairment in crickets that correlates with free thiol depletion.Oxidative damage and amyloid-β metabolism in brain regions of the longest-lived rodents.
P2860
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P2860
Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer disease
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Increased levels of 4-hydroxyn ...... preclinical Alzheimer disease
@ast
Increased levels of 4-hydroxyn ...... preclinical Alzheimer disease
@en
type
label
Increased levels of 4-hydroxyn ...... preclinical Alzheimer disease
@ast
Increased levels of 4-hydroxyn ...... preclinical Alzheimer disease
@en
prefLabel
Increased levels of 4-hydroxyn ...... preclinical Alzheimer disease
@ast
Increased levels of 4-hydroxyn ...... preclinical Alzheimer disease
@en
P2093
P2860
P1476
Increased levels of 4-hydroxyn ...... preclinical Alzheimer disease
@en
P2093
M A Bradley
M A Lovell
W R Markesbery
P2860
P304
P356
10.1016/J.FREERADBIOMED.2010.02.016
P577
2010-02-18T00:00:00Z