Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain.
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8-Oxoguanine DNA glycosylase (OGG1) deficiency increases susceptibility to obesity and metabolic dysfunctionCurcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st centuryAdverse stress, hippocampal networks, and Alzheimer's disease.Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease.A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration.Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer diseaseTau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease.8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization.8-Oxo-7,8-dihydroguanine: links to gene expression, aging, and defense against oxidative stressBmi1 is down-regulated in the aging brain and displays antioxidant and protective activities in neuronsDNA repair deficiency in neurodegeneration.An interplay of the base excision repair and mismatch repair pathways in active DNA demethylation.Elevated 4-hydroxyhexenal in Alzheimer's disease (AD) progressionUrinary 8-hydroxy-2-deoxyguanosine and cognitive function in Puerto Rican adults.Exercise-induced neuroprotection of hippocampus in APP/PS1 transgenic mice via upregulation of mitochondrial 8-oxoguanine DNA glycosylase.Evidence that OGG1 glycosylase protects neurons against oxidative DNA damage and cell death under ischemic conditions.DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes.Oxidatively modified nucleic acids in preclinical Alzheimer's disease (PCAD) brain.Combination of Aβ Secretion and Oxidative Stress in an Alzheimer-Like Cell Line Leads to the Over-Expression of the Nucleotide Excision Repair Proteins DDB2 and XPCSporadic Alzheimer disease fibroblasts display an oxidative stress phenotypeOgg1 null mice exhibit age-associated loss of the nigrostriatal pathway and increased sensitivity to MPTP.Alzheimer's disease-associated neurotoxic peptide amyloid-β impairs base excision repair in human neuroblastoma cellsMitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease.Altered DNA base excision repair profile in brain tissue and blood in Alzheimer's diseaseAmyloid β peptides modify the expression of antioxidant repair enzymes and a potassium channel in the septohippocampal systemBroad DNA repair responses in neural injury are associated with activation of the IL-6 pathway in cholesterol-fed rabbits.Nucleic acid oxidation: an early feature of Alzheimer's disease.The neuropathological profile of mild cognitive impairment (MCI): a systematic review.Nuclear and mitochondrial DNA oxidation in Alzheimer's disease.Oxidative damage to RNA in aging and neurodegenerative disorders.Oxidative DNA damage in disease--insights gained from base excision repair glycosylase-deficient mouse models.8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle.Physical Exercise and Brain Mitochondrial Fitness: The Possible Role Against Alzheimer's Disease.Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?Base excision repair of oxidative DNA damage: from mechanism to disease.The effect of antioxidant vitamins E and C on cognitive performance of the elderly with mild cognitive impairment in Isfahan, Iran: a double-blind, randomized, placebo-controlled trial.Inhibition of phosphodiesterase-4 reverses the cognitive dysfunction and oxidative stress induced by Aβ25-35 in rats.Determination of 8-hydroxy-2'- deoxyguanosine derivatized with 4-chloro-7- nitrobenzofurazan in urine by CE-LIF.Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair.In vivo measurements of interindividual differences in DNA glycosylases and APE1 activities.
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P2860
Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 11 June 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Altered 8-oxoguanine glycosyla ...... age Alzheimer's disease brain.
@en
Altered 8-oxoguanine glycosyla ...... age Alzheimer's disease brain.
@nl
type
label
Altered 8-oxoguanine glycosyla ...... age Alzheimer's disease brain.
@en
Altered 8-oxoguanine glycosyla ...... age Alzheimer's disease brain.
@nl
prefLabel
Altered 8-oxoguanine glycosyla ...... age Alzheimer's disease brain.
@en
Altered 8-oxoguanine glycosyla ...... age Alzheimer's disease brain.
@nl
P2093
P2860
P1476
Altered 8-oxoguanine glycosyla ...... age Alzheimer's disease brain.
@en
P2093
Changxing Shao
Guogen Mao
Mark A Lovell
Shuling Xiong
William R Markesbery
P2860
P304
P356
10.1016/J.FREERADBIOMED.2008.06.003
P50
P577
2008-06-11T00:00:00Z