about
Slow, stochastic transgene repression with properties of a timerReconstructing immune phylogeny: new perspectivesIn vitro antibody evolution targeting germline hot spots to increase activity of an anti-CD22 immunotoxin.A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation.In vitro antibody affinity maturation targeting germline hotspotsThe BRCT domain of PARP-1 is required for immunoglobulin gene conversion.Attracting AID to targets of somatic hypermutation.The protein-protein interface evolution acts in a similar way to antibody affinity maturation.The rate of mutation of a single gene.Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cellsA target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expressionActivation-induced cytidine deaminase (AID)-associated multigene signature to assess impact of AID in etiology of diseases with inflammatory component.Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis.Affinity maturation of anti-TNF-alpha scFv with somatic hypermutation in non-B cells.LINE-1 retroelements complexed and inhibited by activation induced cytidine deaminase.Negative regulation of activation-induced cytidine deaminase in B cellsTargeting of somatic hypermutation.Tuning gene expression with synthetic upstream open reading frames.Separation of mutational and transcriptional enhancers in Ig genes.Splice variants of activation induced deaminase (AID) do not affect the efficiency of class switch recombination in murine CH12F3 cells.Perspective on mutagenesis and repair: the standard model and alternate modes of mutagenesis.AID to overcome the limitations of genomic information.Activation-induced cytidine deaminase (AID) linking immunity, chronic inflammation, and cancerProteasomal degradation restricts the nuclear lifespan of AIDA comprehensive analysis of the effects of the deaminase AID on the transcriptome and methylome of activated B cells.Alternative splicing regulates activation-induced cytidine deaminase (AID): implications for suppression of AID mutagenic activity in normal and malignant B cells.Evolution of new nonantibody proteins via iterative somatic hypermutation.A Novel Regulator of Activation-Induced Cytidine Deaminase/APOBECs in Immunity and Cancer: Schrödinger's CATalytic Pocket.Activation-induced cytidine deaminase in antibody diversification and chromosome translocation.Structural genomic alterations in primary mediastinal large B-cell lymphoma.Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells.Activation-induced cytidine deaminase-mediated sequence diversification is transiently targeted to newly integrated DNA substrates.Activation-induced cytidine deaminase fails to induce a mutator phenotype in the human pre-B cell line Nalm-6.Acetylcholinesterase: converting a vulnerable target to a template for antidotes and detection of inhibitor exposure.Expression of activation-induced cytidine deaminase is associated with a poor prognosis of diffuse large B cell lymphoma patients treated with CHOP-based chemotherapy.Different isoforms of the B-cell mutator activation-induced cytidine deaminase are aberrantly expressed in BCR-ABL1-positive acute lymphoblastic leukemia patients.Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc.Fast directed evolution of non-immunoglobulin proteins by somatic hypermutation in immune cells.Transient AID expression for in situ mutagenesis with improved cellular fitness.
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Genome-wide somatic hypermutation.
@ast
Genome-wide somatic hypermutation.
@en
type
label
Genome-wide somatic hypermutation.
@ast
Genome-wide somatic hypermutation.
@en
prefLabel
Genome-wide somatic hypermutation.
@ast
Genome-wide somatic hypermutation.
@en
P2093
P2860
P356
P1476
Genome-wide somatic hypermutation.
@en
P2093
Clifford L Wang
Matthias Wabl
Ryan A Harper
P2860
P304
P356
10.1073/PNAS.0402009101
P577
2004-04-29T00:00:00Z