A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation. - Wikidata - wikimedia - TriplyDB

A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation.

A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation.

http://www.wikidata.org/entity/Q33398520

about

Epigenetics of Peripheral B-Cell Differentiation and the Antibody Response Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination AID targeting is dependent on RNA polymerase II pausing.Positive Cofactor 4 (PC4) is critical for DNA repair pathway re-routing in DT40 cells Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region.A coming-of-age story: activation-induced cytidine deaminase turns 10.The BRCT domain of PARP-1 is required for immunoglobulin gene conversion.Attracting AID to targets of somatic hypermutation.Generation and repair of AID-initiated DNA lesions in B lymphocytes.Induction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) protein Classical Mus musculus Igκ enhancers support transcription but not high level somatic hypermutation from a V-lambda promoter in chicken DT40 cells.The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia.AID and somatic hypermutation.Controlling somatic hypermutation in immunoglobulin variable and switch regions.AID-initiated DNA lesions are differentially processed in distinct B cell populations.Targeting of AID-mediated sequence diversification to immunoglobulin genes Complex regulation and function of activation-induced cytidine deaminase.Harnessing gene conversion in chicken B cells to create a human antibody sequence repertoire.Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences.Separation of mutational and transcriptional enhancers in Ig genes.Usefulness of a Darwinian system in a biotechnological application: evolution of optical window fluorescent protein variants under selective pressure.Bcl6 Is Required for Somatic Hypermutation and Gene Conversion in Chicken DT40 Cells.Does DNA repair occur during somatic hypermutation?Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.Identification of core DNA elements that target somatic hypermutation.Multiple transcription factor binding sites predict AID targeting in non-Ig genes The IgH 3' regulatory region controls somatic hypermutation in germinal center B cells Defining chromosomal translocation risks in cancer.A critical context-dependent role for E boxes in the targeting of somatic hypermutation.Activation-induced cytidine deaminase-mediated hypermutation in the DT40 cell line.Biochemical basis of immunological and retroviral responses to DNA-targeted cytosine deamination by activation-induced cytidine deaminase and APOBEC3G.AID: a riddle wrapped in a mystery inside an enigma.Technologies of directed protein evolution in vivo.The role of activation-induced deaminase in antibody diversification and genomic instability.Genetic diversification by somatic gene conversion.Bach2 regulates AID-mediated immunoglobulin gene conversion and somatic hypermutation in DT40 B cells.AID Biology: A pathological and clinical perspective.Diversity in the Cow Ultralong CDR H3 Antibody Repertoire.

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A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation.

http://www.wikidata.org/entity/Q33398520

description

2009 nî lūn-bûn

@nan

2009 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

A cis-acting diversification a ...... or AID-mediated hypermutation.

@ast

A cis-acting diversification a ...... or AID-mediated hypermutation.

@en

type

label

A cis-acting diversification a ...... or AID-mediated hypermutation.

@ast

A cis-acting diversification a ...... or AID-mediated hypermutation.

@en

prefLabel

A cis-acting diversification a ...... or AID-mediated hypermutation.

@ast

A cis-acting diversification a ...... or AID-mediated hypermutation.

@en

P1433

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P2860

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P356

JOURNAL.PGEN.1000332

P1433

P1476

A cis-acting diversification a ...... or AID-mediated hypermutation.

@en

P2093

Artem Blagodatski

http://www.w3.org/2001/XMLSchema#string

Hiroshi Arakawa

http://www.w3.org/2001/XMLSchema#string

Jean-Marie Buerstedde

http://www.w3.org/2001/XMLSchema#string

Sabine Schmidl

http://www.w3.org/2001/XMLSchema#string

Ulrike Schoetz

http://www.w3.org/2001/XMLSchema#string

Vera Batrak

http://www.w3.org/2001/XMLSchema#string

P2860

Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution

Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate

Mutant loxP vectors for selectable marker recycle and conditional knock-outs

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

Genome-wide somatic hypermutation.

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

Targeting of somatic hypermutation.

Protein evolution by hypermutation and selection in the B cell line DT40

AID-mediated diversification within the IgL locus of chicken DT40 cells is restricted to the transcribed IgL gene.

P304

e1000332

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1371/JOURNAL.PGEN.1000332

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P433

1

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P478

5

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P50

Randolph B Caldwell

P577

2009-01-09T00:00:00Z

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P5875

23766864

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P698

19132090

http://www.w3.org/2001/XMLSchema#string

P932

2607555

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