Genetic dissection of Alzheimer disease, a heterogeneous disorder.
about
Binding of Abeta to alpha- and beta-synucleins: identification of segments in alpha-synuclein/NAC precursor that bind Abeta and NACThe presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residueInteraction of presenilins with the filamin family of actin-binding proteinsIntroduction of hereditary disease-associated mutations into the beta-amyloid precursor protein gene of mouse embryonic stem cells: a comparison of homologous recombination methodsGenetic Modifiers of Age at Onset in Carriers of the G206A Mutation in PSEN1 With Familial Alzheimer Disease Among Caribbean Hispanics.Genetic bases for common polygenic diseasesStructural variation in human apolipoprotein E3 and E4: secondary structure, tertiary structure, and size distribution.Late onset Alzheimer's disease in older people.Alzheimer diseases: a model of gene mutations and susceptibility polymorphisms for complex psychiatric diseases.Genetics of Alzheimer diseasePresenile dementia syndromes: an update on taxonomy and diagnosis.Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology.The ins and outs of presenilin 1 membrane topology.Apolipoprotein E, not fibrillar β-amyloid, reduces cerebral glucose metabolism in normal aging.HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling.Evidence for phosphorylation and oligomeric assembly of presenilin 1.Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.Propagating structure of Alzheimer's beta-amyloid(10-35) is parallel beta-sheet with residues in exact registerAssessment of normal and mutant human presenilin function in Caenorhabditis elegans.Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model.Premature centromere division of the X chromosome in neurons in Alzheimer's disease.Emerging roles of pathogens in Alzheimer disease.Can cytogenetics explain the possible association between exposure to extreme low-frequency magnetic fields and Alzheimer's disease?Etiology and pathogenesis of late-onset Alzheimer's disease.A family living with Alzheimer's disease: The communicative challenges.Oral inflammation and infection, and chronic medical diseases: implications for the elderly.Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.Brain amyloid--a physicochemical perspective.Recent advances in the genetics of Alzheimer's disease and vascular dementia with an emphasis on gene-environment interactions.Tachykinins, neurotrophism and neurodegenerative diseases: a critical review on the possible role of tachykinins in the aetiology of CNS diseases.Cerebral amyloid beta protein deposits and other Alzheimer lesions in non-demented elderly east Africans.Apolipoprotein E affects amyloid formation but not amyloid growth in vitro: mechanistic implications for apoE4 enhanced amyloid burden and risk for Alzheimer's disease.Genetic epidemiology of Parkinson's disease.All-D-enantiomers of beta-amyloid exhibit similar biological properties to all-L-beta-amyloids.Risk factors and Alzheimer's disease: a comparative study of two communities.An Evolutionarily Conserved Role of Presenilin in Neuronal Protection in the Aging Drosophila Brain.Increased Vulnerability of the Hippocampus in Transgenic Mice Overexpressing APP and Triple Repeat Tau.Metabolic brain networks in aging and preclinical Alzheimer's disease.Down-regulation of H tau 40 protein expression by minor groove binders.: An Etiologic Agent for Late-Onset Dementia
P2860
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P2860
Genetic dissection of Alzheimer disease, a heterogeneous disorder.
description
1995 nî lūn-bûn
@nan
1995 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Genetic dissection of Alzheimer disease, a heterogeneous disorder.
@ast
Genetic dissection of Alzheimer disease, a heterogeneous disorder.
@en
type
label
Genetic dissection of Alzheimer disease, a heterogeneous disorder.
@ast
Genetic dissection of Alzheimer disease, a heterogeneous disorder.
@en
prefLabel
Genetic dissection of Alzheimer disease, a heterogeneous disorder.
@ast
Genetic dissection of Alzheimer disease, a heterogeneous disorder.
@en
P2860
P356
P1476
Genetic dissection of Alzheimer disease, a heterogeneous disorder.
@en
P2093
G D Schellenberg
P2860
P304
P356
10.1073/PNAS.92.19.8552
P407
P577
1995-09-01T00:00:00Z