about
Trafficking regulation of proteins in Alzheimer's diseaseAPP processing in Alzheimer's diseasePresenilin-1 maintains a nine-transmembrane topology throughout the secretory pathwayA nine-transmembrane domain topology for presenilin 1Mutations in ichthyin a new gene on chromosome 5q33 in a new form of autosomal recessive congenital ichthyosis.Transmembrane protein topology mapping by the substituted cysteine accessibility method (SCAM(TM)): application to lipid-specific membrane protein topogenesisEvidence that the COOH terminus of human presenilin 1 is located in extracytoplasmic space.The γ-secretase complex: from structure to function.Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation.Gamma-secretase catalyzes sequential cleavages of the AbetaPP transmembrane domain.The very many faces of presenilins and the γ-secretase complex.Membrane topology of human presenilin-1 in SK-N-SH cells determined by fluorescence correlation spectroscopy and fluorescent energy transfer.gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins.Linear patterns of Alzheimer's disease mutations along alpha-helices of presenilins as a tool for PS-1 model construction.
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The ins and outs of presenilin 1 membrane topology.
@ast
The ins and outs of presenilin 1 membrane topology.
@en
type
label
The ins and outs of presenilin 1 membrane topology.
@ast
The ins and outs of presenilin 1 membrane topology.
@en
prefLabel
The ins and outs of presenilin 1 membrane topology.
@ast
The ins and outs of presenilin 1 membrane topology.
@en
P2860
P356
P1476
The ins and outs of presenilin 1 membrane topology.
@en
P2860
P304
P356
10.1073/PNAS.0307297101
P407
P577
2004-01-19T00:00:00Z