HLA-DR-restricted T-cell responses to factor VIII epitopes in a mild haemophilia A family with missense substitution A2201P.
about
Dangerous liaisons: how the immune system deals with factor VIIIHaemophilia management: time to get personal?Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti-factor VIII immune responses.High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance.T-cell responses in two unrelated hemophilia A inhibitor subjects include an epitope at the factor VIII R593C missense site.Immunogenicity to biologics: mechanisms, prediction and reduction.Inhibitors - cellular aspects and novel approaches for tolerance.Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses.Design of the INHIBIT trial: preventing inhibitors by avoiding 'danger', prolonging half-life and promoting tolerance.Factor VIII gene variants and inhibitor risk in African American hemophilia A patientsAvidity of human T cell receptor engineered CD4(+) T cells drives T-helper differentiation fateProgress toward inducing immunologic tolerance to factor VIII.New predictive approaches for ITI treatment.Engineering less immunogenic and antigenic FVIII proteins.Hemophilia A inhibitor treatment: the promise of engineered T-cell therapy.HLA-DR-presented peptide repertoires derived from human monocyte-derived dendritic cells pulsed with blood coagulation factor VIII.Human Tregs Made Antigen Specific by Gene Modification: The Power to Treat Autoimmunity and Antidrug Antibodies with PrecisionLimited promiscuity of HLA-DRB1 presented peptides derived of blood coagulation factor VIII.T cells from hemophilia A subjects recognize the same HLA-restricted FVIII epitope with a narrow TCR repertoire.Predictive immunogenicity of Refacto AF.
P2860
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P2860
HLA-DR-restricted T-cell responses to factor VIII epitopes in a mild haemophilia A family with missense substitution A2201P.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
HLA-DR-restricted T-cell respo ...... missense substitution A2201P.
@ast
HLA-DR-restricted T-cell respo ...... missense substitution A2201P.
@en
type
label
HLA-DR-restricted T-cell respo ...... missense substitution A2201P.
@ast
HLA-DR-restricted T-cell respo ...... missense substitution A2201P.
@en
prefLabel
HLA-DR-restricted T-cell respo ...... missense substitution A2201P.
@ast
HLA-DR-restricted T-cell respo ...... missense substitution A2201P.
@en
P2093
P2860
P921
P1433
P1476
HLA-DR-restricted T-cell respo ...... missense substitution A2201P.
@en
P2093
A R Thompson
R A Ettinger
P2860
P356
10.1111/J.1365-2516.2008.01905.X
P577
2010-05-01T00:00:00Z