Flavopiridol inhibits P-TEFb and blocks HIV-1 replication. - Wikidata - wikimedia - TriplyDB

Flavopiridol inhibits P-TEFb and blocks HIV-1 replication.

Flavopiridol inhibits P-TEFb and blocks HIV-1 replication.

http://www.wikidata.org/entity/Q33910799

about

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex Identification of HEXIM1 as a positive regulator of p53 The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression RNA helicase DDX21 coordinates transcription and ribosomal RNA processing The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation Phosphorylation of the RNA polymerase II carboxyl-terminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription Roscovitine inhibits activation of promoters in herpes simplex virus type 1 genomes independently of promoter-specific factors c-Myc regulates transcriptional pause release LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated Regulation of P-TEFb elongation complex activity by CDK9 acetylation HIV-1 expression induces cyclin D1 expression and pRb phosphorylation in infected podocytes: cell-cycle mechanisms contributing to the proliferative phenotype in HIV-associated nephropathy.Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol P-TEFb goes viral Targeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitors Comparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype Selectivity The lab oddity prevails: discovery of pan-CDK inhibitor (R)-S-cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide (BAY 1000394) for the treatment of cancer BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain Interactions between the aryl hydrocarbon receptor and P-TEFb. Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at cyp1a1 promoter A highly purified RNA polymerase II elongation control system Misguided transcriptional elongation causes mixed lineage leukemia HEXIM1 induces differentiation of human pluripotent stem cells Molecular dynamics simulation and experimental verification of the interaction between cyclin T1 and HIV-1 Tat proteins Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II The positive transcription elongation factor b is an essential cofactor for the activation of transcription by myocyte enhancer factor 2 Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element Menin enhances c-Myc-mediated transcription to promote cancer progression Site-specific regulation of histone H1 phosphorylation in pluripotent cell differentiation Controlling cellular P-TEFb activity by the HIV-1 transcriptional transactivator Tat Potent inhibition of rhabdoid tumor cells by combination of flavopiridol and 4OH-tamoxifen.Changes in histone H3 lysine 36 methylation in porcine oocytes and preimplantation embryos.Induction of TAK (cyclin T1/P-TEFb) in purified resting CD4(+) T lymphocytes by combination of cytokines.The CDK9/cyclin T1 subunits of P-TEFb in mouse oocytes and preimplantation embryos: a possible role in embryonic genome activation.Targeting MET transcription as a therapeutic strategy in multiple myeloma.Phase I clinical and pharmacokinetic study of a novel schedule of flavopiridol in relapsed or refractory acute leukemias.Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1.microRNA machinery is an integral component of drug-induced transcription inhibition in HIV-1 infection.Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo.

P2860

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P2860

Flavopiridol inhibits P-TEFb and blocks HIV-1 replication.

http://www.wikidata.org/entity/Q33910799

description

2000 nî lūn-bûn

@nan

2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2000年の論文

@ja

2000年論文

@yue

2000年論文

@zh-hant

2000年論文

@zh-hk

2000年論文

@zh-mo

2000年論文

@zh-tw

2000年论文

@wuu

name

Flavopiridol inhibits P-TEFb and blocks HIV-1 replication.

@ast

Flavopiridol inhibits P-TEFb and blocks HIV-1 replication.

@en

type

label

Flavopiridol inhibits P-TEFb and blocks HIV-1 replication.

@ast

Flavopiridol inhibits P-TEFb and blocks HIV-1 replication.

@en

prefLabel

Flavopiridol inhibits P-TEFb and blocks HIV-1 replication.

@ast

Flavopiridol inhibits P-TEFb and blocks HIV-1 replication.

@en

P1433

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P1433

Journal of Biological Chemistry

P1476

Flavopiridol inhibits P-TEFb and blocks HIV-1 replication.

@en

P2093

Chao SH

http://www.w3.org/2001/XMLSchema#string

Fujinaga K

http://www.w3.org/2001/XMLSchema#string

Marion JE

http://www.w3.org/2001/XMLSchema#string

Peterlin BM

http://www.w3.org/2001/XMLSchema#string

Price DH

http://www.w3.org/2001/XMLSchema#string

Sausville EA

http://www.w3.org/2001/XMLSchema#string

Senderowicz AM

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Taube R

http://www.w3.org/2001/XMLSchema#string

P2860

Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro

Identification of multiple cyclin subunits of human P-TEFb

A protein phosphatase functions to recycle RNA polymerase II

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription

NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation

A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA

Role of the human homolog of the yeast transcription factor SPT5 in HIV-1 Tat-activation

Regulation of carboxyl-terminal domain phosphatase by HIV-1 tat protein

Upregulation of cyclin T1/CDK9 complexes during T cell activation

P304

28345-28348

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scholarly article

P356

10.1074/JBC.C000446200

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P407

P433

37

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P478

275

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P577

2000-09-01T00:00:00Z

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P698

10906320

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