Upregulation of cyclin T1/CDK9 complexes during T cell activation
about
The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expressionCyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent mannerAcetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcriptionInteraction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasomeRelief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoterActivation of MyoD-dependent transcription by cdk9/cyclin T2Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcriptionAntiviral activity of CYC202 in HIV-1-infected cellsInhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitorsP-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase IICellular mRNA activates transcription elongation by displacing 7SK RNA.Negative elongation factor is required for the maintenance of proviral latency but does not induce promoter-proximal pausing of RNA polymerase II on the HIV long terminal repeat.Antiapoptotic function of Cdk9 (TAK/P-TEFb) in U937 promonocytic cells.Induction of TAK (cyclin T1/P-TEFb) in purified resting CD4(+) T lymphocytes by combination of cytokines.Flavopiridol inhibits P-TEFb and blocks HIV-1 replication.T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes.Human cytomegalovirus infection induces specific hyperphosphorylation of the carboxyl-terminal domain of the large subunit of RNA polymerase II that is associated with changes in the abundance, activity, and localization of cdk9 and cdk7.RNA polymerase II transcription elongation control.CDK9 is constitutively expressed throughout the cell cycle, and its steady-state expression is independent of SKP2.Selective HDAC inhibition for the disruption of latent HIV-1 infection.Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemia.Activation of P-TEFb at sites of dual HIV/TB infection, and inhibition of MTB-induced HIV transcriptional activation by the inhibitor of CDK9, Indirubin-3'-monoxime.Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes.Use of ATP analogs to inhibit HIV-1 transcription.Increased cyclin T1 expression as a favorable prognostic factor in treating gastric adenocarcinoma.Direct inhibition of CDK9 blocks HIV-1 replication without preventing T-cell activation in primary human peripheral blood lymphocytes.Serum cyclin-dependent kinase 9 is a potential biomarker of atherosclerotic inflammation.Cyclins and cell cycle control in cancer and disease.Inhibition of HIV-1 transcription and replication by a newly identified cyclin T1 splice variant.Positive cyclin T expression as a favorable prognostic factor in treating gastric gastrointestinal stromal tumors.Dormancy activation mechanism of tracheal stem cells.Selective control of gene expression by CDK9 in human cellsCuring HIV: Pharmacologic approaches to target HIV-1 latency.RNA polymerase II elongation control.Perspective of cyclin-dependent kinase 9 (CDK9) as a drug target.Restrictions to HIV-1 replication in resting CD4+ T lymphocytes.Deregulations in the cyclin-dependent kinase-9-related pathway in cancer: implications for drug discovery and development.HIV-1 replication and latency are regulated by translational control of cyclin T1Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells.Binding of Tat to TAR and recruitment of positive transcription elongation factor b occur independently in bovine immunodeficiency virus.
P2860
Q24298498-38F87625-7017-46E6-B625-737B35F2C694Q24301811-6C2A624E-689C-4391-94B2-99042E6567BBQ24310643-809F3BAA-AB87-43C3-B0D6-0FDC06942F98Q24548261-75906192-3D22-4F69-823B-069929DCB34BQ24552532-9EE195BA-B979-4919-A9DF-5BE97AE5F2D7Q28115623-C026A54C-796B-48FF-9EBE-538F04BB7FD4Q28138707-83994703-72A3-4725-B852-4F77FBD56F77Q28292152-0D62688D-02AE-4F29-80D3-60DE94B455AAQ28344365-11A61811-B8B4-4D76-8442-AD791958C461Q29620167-FD28CC46-4C50-429F-B957-0A18FDFCC02CQ33302108-6344820C-94DE-42CF-9B56-217252056AB3Q33602605-EFB0F034-9A9E-4F13-AAA0-C72FE3B25FBBQ33836069-747B69B7-FE52-4E2C-9635-20D38921B93EQ33849629-CD7CFAAF-6393-43A1-8C92-43FD2EF5ED61Q33910799-6F9AA1E3-5A92-4032-9CBE-EE304F5A417FQ33922921-DD7CF45C-E2F1-4A58-B2E5-859CD659FB5FQ34228694-DE4C16D8-86FD-49AC-B60B-038183D5C8E1Q34960186-76EE57E8-10F9-4A7F-B671-323A66EFA870Q35161639-45FB451A-5578-4CE4-9F2E-BE9071E536C3Q35227888-7FB7473C-1E0B-49EA-B972-21D81E2FFF13Q35550068-9B344ABB-F1BB-445D-B262-497F87F4809FQ35746236-AEA87CC3-A70B-4224-A8DE-344AAD753187Q35826285-2FE1C95A-FCFB-4D67-B83D-0D93351376FFQ36202709-AE64656F-3FB0-4CE0-BE66-8A06937179EFQ36334152-339D839C-DF6B-44EC-8A4A-1112B1D8EC89Q36419687-82EA5AC7-EEED-45E9-9DD0-250D1D3413C5Q36738991-F4031364-5541-4A48-AFDB-3B28470D805EQ36796438-9489182E-DE98-4721-BA3F-F0D2376ACCE3Q36850296-8329B3C5-5EA4-42D4-808B-EECC79C2C7D6Q36953714-79C91B54-376A-4CD4-8625-FB4FA5533998Q37269112-BFEE4246-75B7-4A92-A523-7D2273B8F760Q37437860-71A16130-265F-4E5C-8FCC-93F72DDF0EA3Q37645582-A5B6BB30-3403-46DE-B300-96652850BA26Q37992154-044C6CFF-43D6-45DD-A321-BDD80CE7E185Q38008733-C3FCF58D-A7B6-4C44-B805-C031FA6E0B4DQ38111619-880561D4-40E5-45B5-9F13-8A142AFA4A50Q38120534-B76A3123-5C9F-4D9D-A9F4-1B79D32312A1Q38273477-30B61063-EED4-45E5-883C-13EE6FA1461BQ38557763-4D6E4C8B-063E-4CA5-BBE1-25BE8F41D097Q39591738-D6AEF624-D034-4D65-8F48-79EE9B6D0507
P2860
Upregulation of cyclin T1/CDK9 complexes during T cell activation
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Upregulation of cyclin T1/CDK9 complexes during T cell activation
@ast
Upregulation of cyclin T1/CDK9 complexes during T cell activation
@en
Upregulation of cyclin T1/CDK9 complexes during T cell activation
@nl
type
label
Upregulation of cyclin T1/CDK9 complexes during T cell activation
@ast
Upregulation of cyclin T1/CDK9 complexes during T cell activation
@en
Upregulation of cyclin T1/CDK9 complexes during T cell activation
@nl
prefLabel
Upregulation of cyclin T1/CDK9 complexes during T cell activation
@ast
Upregulation of cyclin T1/CDK9 complexes during T cell activation
@en
Upregulation of cyclin T1/CDK9 complexes during T cell activation
@nl
P2093
P356
P1433
P1476
Upregulation of cyclin T1/CDK9 complexes during T cell activation
@en
P2093
P2888
P304
P356
10.1038/SJ.ONC.1202548
P407
P577
1998-12-17T00:00:00Z
P5875
P6179
1003693231