ERK phosphorylates p66shcA on Ser36 and subsequently regulates p27kip1 expression via the Akt-FOXO3a pathway: implication of p27kip1 in cell response to oxidative stress. - Wikidata - wikimedia - TriplyDB

ERK phosphorylates p66shcA on Ser36 and subsequently regulates p27kip1 expression via the Akt-FOXO3a pathway: implication of p27kip1 in cell response to oxidative stress.

ERK phosphorylates p66shcA on Ser36 and subsequently regulates p27kip1 expression via the Akt-FOXO3a pathway: implication of p27kip1 in cell response to oxidative stress.

http://www.wikidata.org/entity/Q33911129

about

Mammalian sterile 20-like kinase 3 (MST3) mediates oxidative-stress-induced cell death by modulating JNK activation Something old, something new, something borrowed; how the thermoacidophilic archaeon Sulfolobus solfataricus responds to oxidative stress Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function.The oxidative stress adaptor p66Shc is required for permanent embryo arrest in vitro.SOD3 decreases ischemic injury derived apoptosis through phosphorylation of Erk1/2, Akt, and FoxO3a.Smoking p66Shc knocked out mice develop respiratory bronchiolitis with fibrosis but not emphysema HIV gene expression deactivates redox-sensitive stress response program in mouse tubular cells both in vitro and in vivo.Pigment epithelium-derived factor inhibits neointimal hyperplasia after vascular injury by blocking NADPH oxidase-mediated reactive oxygen species generation.ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation.Novel role of p66Shc in ROS-dependent VEGF signaling and angiogenesis in endothelial cells Endothelin-1 couples betaPix to p66Shc: role of betaPix in cell proliferation through FOXO3a phosphorylation and p27kip1 down-regulation independently of Akt Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells FOXO3a inhibits TNF-α- and IL-1β-induced astrocyte proliferation:Implication for reactive astrogliosis Inhibition of p66ShcA longevity gene rescues podocytes from HIV-1-induced oxidative stress and apoptosis Arginase-II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its l-arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerability Endothelin-1 induces p66Shc activation through EGF receptor transactivation: Role of beta(1)Pix/Galpha(i3) interaction.Applications of post-translational modifications of FoxO family proteins in biological functions.The Role of p66shc in Oxidative Stress and Apoptosis.Oxidative stress, a common molecular pathway for kidney disease: role of the redox enzyme p66Shc.Modelling the p53/p66Shc Aging Pathway in the Shortest Living Vertebrate Nothobranchius Furzeri.Parathyroid Hormone-Related Protein Protects Osteoblastic Cells From Oxidative Stress by Activation of MKP1 Phosphatase.Effects of Resveratrol on p66Shc phosphorylation in cultured prostate cells.Anthocyanins Protect SK-N-SH Cells Against Acrolein-Induced Toxicity by Preserving the Cellular Redox State.Salicin, an extract from white willow bark, inhibits angiogenesis by blocking the ROS-ERK pathways.SHetA2 interference with mortalin binding to p66shc and p53 identified using drug-conjugated magnetic microspheres The anti-angiogenic activities of glycyrrhizic acid in tumor progression.Phosphorylation of p66shc mediates 6-hydroxydopamine cytotoxicity.High Erk activity suppresses expression of the cell cycle inhibitor p27Kip1 in colorectal cancer cells p66shc inhibits pro-survival epidermal growth factor receptor/ERK signaling during severe oxidative stress in mouse renal proximal tubule cells.AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation.Regulation of FOXO3a/beta-catenin/GSK-3beta signaling by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells.Synaptic activity and nuclear calcium signaling protect hippocampal neurons from death signal-associated nuclear translocation of FoxO3a induced by extrasynaptic N-methyl-D-aspartate receptors The effect of nutritionally induced hyperlipidaemia on in vitro bovine embryo quality.The p66(Shc) redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells.A Rationale for Targeting Extracellular Regulated Kinases ERK1 and ERK2 in Glioblastoma.Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics.Mechanisms in cardiac fibroblast growth: an obligate role for Skp2 and FOXO3a in ERK1/2 MAPK-dependent regulation of p27kip1.

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P2860

ERK phosphorylates p66shcA on Ser36 and subsequently regulates p27kip1 expression via the Akt-FOXO3a pathway: implication of p27kip1 in cell response to oxidative stress.

http://www.wikidata.org/entity/Q33911129

description

2005 nî lūn-bûn

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2005 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի հունիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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ERK phosphorylates p66shcA on ...... response to oxidative stress.

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ERK phosphorylates p66shcA on ...... response to oxidative stress.

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ERK phosphorylates p66shcA on ...... response to oxidative stress.

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MBC.E05-04-0301

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Molecular Biology of the Cell

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Baojie Li

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De-Yu Cai

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Eduardo J Firpo

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Kanaga Sabapathy

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Li Zeng

http://www.w3.org/2001/XMLSchema#string

Stephen P Goff

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Xueying Wang

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Yuanyu Hu

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P2860

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling

Cell signaling by receptor tyrosine kinases

Free radicals in the physiological control of cell function

Signal transduction by receptors with tyrosine kinase activity

A C. elegans mutant that lives twice as long as wild type

Oxidants, oxidative stress and the biology of ageing

Signaling via Shc family adapter proteins

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10.1091/MBC.E05-04-0301

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8

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16

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7812255

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15930121

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phosphorylation

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1182309

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