Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors.
about
Prey-Capture Strategies of Fish-Hunting Cone Snails: Behavior, Neurobiology and Evolution.From molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypesIn the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compoundsQ28831186Antagonistic action on NMDA/GluN2B mediated currents of two peptides that were conantokin-G structure-based designedLigands for ionotropic glutamate receptorsConantokins inhibit NMDAR-dependent calcium influx in developing rat hippocampal neurons in primary culture with resulting effects on CREB phosphorylation.Conantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits.Conotoxin gene superfamilies.Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor.Opposing action of conantokin-G on synaptically and extrasynaptically-activated NMDA receptors.Differences in excitatory transmission between thalamic and cortical afferents to single spiny efferent neurons of rat dorsal striatumNR2B-selective conantokin peptide inhibitors of the NMDA receptor display enhanced antinociceptive properties compared to non-selective conantokins.Blockade of hindbrain NMDA receptors containing NR2 subunits increases sucrose intakeNon-strict strand orientation of the Ca2+-induced dimerization of a conantokin peptide variant with sequence-shifted gamma-carboxyglutamate residuesCell type-specific development of NMDA receptors in the interneurons of rat prefrontal cortex.Neuroprotective and cardioprotective conopeptides: an emerging class of drug leads.CGX-1007 prevents excitotoxic cell death via actions at multiple types of NMDA receptors.Probing NMDA receptor GluN2A and GluN2B subunit expression and distribution in cortical neurons.Subtype-selective antagonism of N-methyl-D-aspartate receptor ion channels by synthetic conantokin peptides.Leptin enhances NR2B-mediated N-methyl-D-aspartate responses via a mitogen-activated protein kinase-dependent process in cerebellar granule cells.Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations.The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B.Specific determinants of conantokins that dictate their selectivity for the NR2B subunit of N-methyl-D-aspartate receptors.Conotoxins: Therapeutic Potential and Application.
P2860
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P2860
Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors.
description
2000 nî lūn-bûn
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2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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Conantokin G is an NR2B-select ...... -methyl-D-aspartate receptors.
@ast
Conantokin G is an NR2B-select ...... -methyl-D-aspartate receptors.
@en
type
label
Conantokin G is an NR2B-select ...... -methyl-D-aspartate receptors.
@ast
Conantokin G is an NR2B-select ...... -methyl-D-aspartate receptors.
@en
prefLabel
Conantokin G is an NR2B-select ...... -methyl-D-aspartate receptors.
@ast
Conantokin G is an NR2B-select ...... -methyl-D-aspartate receptors.
@en
P1476
Conantokin G is an NR2B-select ...... -methyl-D-aspartate receptors.
@en
P2093
P304
P577
2000-09-01T00:00:00Z