NR2B-selective conantokin peptide inhibitors of the NMDA receptor display enhanced antinociceptive properties compared to non-selective conantokins.

NR2B-selective conantokin peptide inhibitors of the NMDA receptor display enhanced antinociceptive properties compared to non-selective conantokins.

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http://www.wikidata.org/entity/Q37052031
Antagonist properties of Conus parius peptides on N-methyl-D-aspartate receptors and their effects on CREB signalingConantokins inhibit NMDAR-dependent calcium influx in developing rat hippocampal neurons in primary culture with resulting effects on CREB phosphorylation.Conantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits.Conantokin-G attenuates detrimental effects of NMDAR hyperactivity in an ischemic rat model of stroke.Hydroxyproline-induced Helical Disruption in Conantokin Rl-B Affects Subunit-selective Antagonistic Activities toward Ion Channels of N-Methyl-d-aspartate Receptors.CGX-1007 prevents excitotoxic cell death via actions at multiple types of NMDA receptors.Probing NMDA receptor GluN2A and GluN2B subunit expression and distribution in cortical neurons.Specific determinants of conantokins that dictate their selectivity for the NR2B subunit of N-methyl-D-aspartate receptors.Synthetic conantokin peptides potently inhibit N-methyl-D-aspartate receptor-mediated currents of retinal ganglion cells.Polymethoxyflavones from Nicotiana plumbaginifolia (Solanaceae) Exert Antinociceptive and Neuropharmacological Effects in Mice.
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NR2B-selective conantokin peptide inhibitors of the NMDA receptor display enhanced antinociceptive properties compared to non-selective conantokins.

Item
http://www.wikidata.org/entity/Q37052031
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
NR2B-selective conantokin pept ...... to non-selective conantokins.
@en
NR2B-selective conantokin pept ...... to non-selective conantokins.
@nl
type
label
NR2B-selective conantokin pept ...... to non-selective conantokins.
@en
NR2B-selective conantokin pept ...... to non-selective conantokins.
@nl
prefLabel
NR2B-selective conantokin pept ...... to non-selective conantokins.
@en
NR2B-selective conantokin pept ...... to non-selective conantokins.
@nl
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NR2B-selective conantokin pept ...... to non-selective conantokins.
@en
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P2860
P304
P31
P356
10.1016/J.NPEP.2008.09.003
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P478
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P5875
P698
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