The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche.
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Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cellsThe unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein foldingDifferential requirement of GRP94 and GRP78 in mammary gland development.Acute inducible ablation of GRP78 reveals its role in hematopoietic stem cell survival, lymphogenesis and regulation of stress signaling.Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis.New fusion transcripts identified in normal karyotype acute myeloid leukemia.Targeted deletion of ER chaperone GRP94 in the liver results in injury, repopulation of GRP94-positive hepatocytes, and spontaneous hepatocellular carcinoma development in aged miceHsp90 C-terminal inhibitors exhibit antimigratory activity by disrupting the Hsp90α/Aha1 complex in PC3-MM2 cells.High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in miceInducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signalingThe molecular chaperone gp96/GRP94 interacts with Toll-like receptors and integrins via its C-terminal hydrophobic domainRole of the unfolded protein response, GRP78 and GRP94 in organ homeostasis.Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development.Hsp90 regulation of mitochondrial protein folding: from organelle integrity to cellular homeostasisDeficiency of GRP94 in the hematopoietic system alters proliferation regulators in hematopoietic stem cells.GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN.TRAP-1, the mitochondrial Hsp90.Ex vivo expansion of umbilical cord blood: where are we?The hematopoietic stem cell niche--home for friend and foe?Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potentialMZB1 is a GRP94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon ER stress.
P2860
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P2860
The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The endoplasmic reticulum chap ...... h the adult bone marrow niche.
@ast
The endoplasmic reticulum chap ...... h the adult bone marrow niche.
@en
type
label
The endoplasmic reticulum chap ...... h the adult bone marrow niche.
@ast
The endoplasmic reticulum chap ...... h the adult bone marrow niche.
@en
prefLabel
The endoplasmic reticulum chap ...... h the adult bone marrow niche.
@ast
The endoplasmic reticulum chap ...... h the adult bone marrow niche.
@en
P2093
P2860
P1433
P1476
The endoplasmic reticulum chap ...... h the adult bone marrow niche.
@en
P2093
Biquan Luo
Gregor B Adams
Shiuan Wey
Si-Yi Chen
Sung Hyung Lee
P2860
P304
P356
10.1371/JOURNAL.PONE.0020364
P407
P577
2011-05-24T00:00:00Z