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Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice

Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice

http://www.wikidata.org/entity/Q33925237

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How genetically engineered systems are helping to define, and in some cases redefine, the neurobiological basis of sleep and wake Physiology of the orexinergic/hypocretinergic system: a revisit in 2012 The hypocretins/orexins: integrators of multiple physiological functions Optogenetics in psychiatric diseases Narcolepsy: neural mechanisms of sleepiness and cataplexy Turning a Negative into a Positive: Ascending GABAergic Control of Cortical Activation and Arousal The regulation of sleep and wakefulness by the hypothalamic neuropeptide orexin/hypocretin The physiological role of orexin/hypocretin neurons in the regulation of sleep/wakefulness and neuroendocrine functions Neurons containing orexin or melanin concentrating hormone reciprocally regulate wake and sleep Diaschisis: past, present, future Light-emitting channelrhodopsins for combined optogenetic and chemical-genetic control of neurons Pharmacosynthetics: Reimagining the pharmacogenetic approach Whole-brain circuit dissection in free-moving animals reveals cell-specific mesocorticolimbic networks DREADDs in Drosophila: a pharmacogenetic approach for controlling behavior, neuronal signaling, and physiology in the fly.Orexin neurons suppress narcolepsy via 2 distinct efferent pathways.Opposing effects of acute versus chronic blockade of frontal cortex somatostatin-positive inhibitory neurons on behavioral emotionality in mice.Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson's disease Tools for resolving functional activity and connectivity within intact neural circuits.Orexin neurons receive glycinergic innervations.Long-term Cre-mediated retrograde tagging of neurons using a novel recombinant pseudorabies virus Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns.The orexin neuropeptide system: physical activity and hypothalamic function throughout the aging process.Enhanced slow-wave EEG activity and thermoregulatory impairment following the inhibition of the lateral hypothalamus in the rat.The effect of orexin-A on cardiac dysfunction mediated by NADPH oxidase-derived superoxide anion in ventrolateral medulla.An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females.Medial amygdalar aromatase neurons regulate aggression in both sexes.Optogenetic evidence for inhibitory signaling from orexin to MCH neurons via local microcircuits Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: pharmacological and behavioral genetics evidence.DREADD-Induced Silencing of the Medial Olfactory Tubercle Disrupts the Preference of Female Mice for Opposite-Sex Chemosignals(1,2,3).The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors.Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse.DREADDs for Neuroscientists.Role of orexin in modulating arousal, feeding, and motivation.Lateral Hypothalamus GABAergic Neurons Modulate Consummatory Behaviors Regardless of the Caloric Content or Biological Relevance of the Consumed Stimuli.Functional wiring of hypocretin and LC-NE neurons: implications for arousal A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons.Basal Forebrain Cholinergic Neurons Primarily Contribute to Inhibition of Electroencephalogram Delta Activity, Rather Than Inducing Behavioral Wakefulness in Mice Novel designer receptors to probe GPCR signaling and physiology Disruption of centrifugal inhibition to olfactory bulb granule cells impairs olfactory discrimination.

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Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice

http://www.wikidata.org/entity/Q33925237

description

2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice

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Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice

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type

label

Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice

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Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice

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prefLabel

Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice

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Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice

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JOURNAL.PONE.0020360

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Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice

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Bryan Roth

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Koh Sasaki

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Michihiro Mieda

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Mika Suzuki

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Natsuko Tsujino

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Takeshi Sakurai

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P2860

Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand

Neural substrates of awakening probed with optogenetic control of hypocretin neurons

Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning

Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

Orexin A activates locus coeruleus cell firing and increases arousal in the rat.

Isolation of highly infectious and pure adeno-associated virus type 2 vectors with a single-step gravity-flow column.

Fos expression in orexin neurons varies with behavioral state.

Selective activation of the extended ventrolateral preoptic nucleus during rapid eye movement sleep.

Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor.

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