Both protein dynamics and ligand concentration can shift the binding mechanism between conformational selection and induced fit
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Insights into Protein-Ligand Interactions: Mechanisms, Models, and MethodsQuantitatively characterizing the ligand binding mechanisms of choline binding protein using Markov state model analysisHow to Distinguish Conformational Selection and Induced Fit Based on Chemical Relaxation RatesEmerging Computational Methods for the Rational Discovery of Allosteric Drugs.Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered proteinConformational preferences underlying reduced activity of a thermophilic ribonuclease H.Markov State Models Reveal a Two-Step Mechanism of miRNA Loading into the Human Argonaute Protein: Selective Binding followed by Structural Re-arrangement.Conformational kinetics reveals affinities of protein conformational states.A Systematic Analysis of the Structures of Heterologously Expressed Proteins and Those from Their Native Hosts in the RCSB PDB Archive.Protein Allostery and Conformational Dynamics.Structure and dynamics underlying elementary ligand binding events in human pacemaking channelsFlexible receptor docking for drug discovery.Rate Constants and Mechanisms of Protein-Ligand Binding.The advancement of multidimensional QSAR for novel drug discovery - where are we headed?Pushing the Backbone in Protein-Protein Docking.Real-time single-molecule studies of the motions of DNA polymerase fingers illuminate DNA synthesis mechanismsConformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis.Model structures of inactive and peptide agonist bound C5aR: Insights into agonist binding, selectivity and activation.A Kinetic Signature for Parallel Pathways: Conformational Selection and Induced Fit. Links and Disconnects between Observed Relaxation Rates and Fractional Equilibrium Flux under Pseudo-First-Order Conditions.Unified understanding of folding and binding mechanisms of globular and intrinsically disordered proteins.Protein conformational flexibility modulates kinetics and thermodynamics of drug binding."Multiple partial recognitions in dynamic equilibrium" in the binding sites of proteins form the molecular basis of promiscuous recognition of structurally diverse ligands.Dynamics of the conformational transitions during the dimerization of an intrinsically disordered peptide: a case study on the human islet amyloid polypeptide fragment.Communication: Resonance reaction in diffusion-influenced bimolecular reactions.Exploring the structural origins of cryptic sites on proteins.Protein dynamic communities from elastic network models align closely to the communities defined by molecular dynamics.
P2860
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P2860
Both protein dynamics and ligand concentration can shift the binding mechanism between conformational selection and induced fit
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Both protein dynamics and liga ...... onal selection and induced fit
@ast
Both protein dynamics and liga ...... onal selection and induced fit
@en
type
label
Both protein dynamics and liga ...... onal selection and induced fit
@ast
Both protein dynamics and liga ...... onal selection and induced fit
@en
prefLabel
Both protein dynamics and liga ...... onal selection and induced fit
@ast
Both protein dynamics and liga ...... onal selection and induced fit
@en
P2860
P356
P1476
Both protein dynamics and liga ...... onal selection and induced fit
@en
P2093
Nicholas Greives
P2860
P304
10197-10202
P356
10.1073/PNAS.1407545111
P407
P577
2014-06-30T00:00:00Z