Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection.
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Viral evolution and escape during acute HIV-1 infectionThe hope for an HIV vaccine based on induction of CD8+ T lymphocytes--a reviewEfficacious early antiviral activity of HIV Gag- and Pol-specific HLA-B 2705-restricted CD8+ T cellsAltered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques.Monitoring the T-cell receptor repertoire at single-clone resolution.CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation.Host HLA B*allele-associated multi-clade Gag T-cell recognition correlates with slow HIV-1 disease progression in antiretroviral therapy-naïve Ugandans.Two MHC class I molecules associated with elite control of immunodeficiency virus replication, Mamu-B*08 and HLA-B*2705, bind peptides with sequence similarity.Vaccination with Gag, Vif, and Nef gene fragments affords partial control of viral replication after mucosal challenge with SIVmac239Broad cross-clade T-cell responses to gag in individuals infected with human immunodeficiency virus type 1 non-B clades (A to G): importance of HLA anchor residue conservation.Immune dysregulation in human immunodeficiency virus infection: know it, fix it, prevent it?De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infectionTh-1-type cytotoxic CD8+ T-lymphocyte responses to simian immunodeficiency virus (SIV) are a consistent feature of natural SIV infection in sooty mangabeys.Immunotherapy coming of age: what will it take to make it standard of care for glioblastoma?Expansion and diversification of virus-specific T cells following immunization of human immunodeficiency virus type 1 (HIV-1)-infected individuals with a recombinant modified vaccinia virus Ankara/HIV-1 Gag vaccine.Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trial.Induction of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses in HIV vaccine trial participants who subsequently acquire HIV-1 infection.A DNA prime-oral Listeria boost vaccine in rhesus macaques induces a SIV-specific CD8 T cell mucosal response characterized by high levels of alpha4beta7 integrin and an effector memory phenotype.High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV controlHIV-mediated phosphatidylinositol 3-kinase/serine-threonine kinase activation in APCs leads to programmed death-1 ligand upregulation and suppression of HIV-specific CD8 T cells.T cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cellsIn vitro sensitization of T cells with DC-associated/delivered HIV constructs can induce a polyfunctional CTL response, memory T-cell response, and virus suppressionSubdominant CD8+ T-cell responses are involved in durable control of AIDS virus replication.Immune-mediated attenuation of HIV-1Human CD4+ T Helper Cell Responses after Tick-Borne Encephalitis Vaccination and Infection.Cellular immune correlates analysis of an HIV-1 preexposure prophylaxis trial.HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS.Profile of T cell recognition of HIV type 1 consensus group M Gag and Nef peptides in a clade A1- and D-infected Ugandan population.Recognition of a defined region within p24 gag by CD8+ T cells during primary human immunodeficiency virus type 1 infection in individuals expressing protective HLA class I allelesModified vaccinia virus Ankara-based vaccine vectors induce apoptosis in dendritic cells draining from the skin via both the extrinsic and intrinsic caspase pathways, preventing efficient antigen presentation.HIV-1 Subtype C Mosaic Gag Expressed by BCG and MVA Elicits Persistent Effector T Cell Responses in a Prime-Boost Regimen in MiceValidation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood.DNA prime-adenovirus boost immunization induces a vigorous and multifunctional T-cell response against hepadnaviral proteins in the mouse and woodchuck model.Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8+ T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection.Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replicationPatterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control simian immunodeficiency virus SIVmac239 replication.Primary human immunodeficiency virus type 1 (HIV-1) infection during HIV-1 Gag vaccination.Th1 memory: implications for vaccine development.Antiviral therapy during primary simian immunodeficiency virus infection fails to prevent acute loss of CD4+ T cells in gut mucosa but enhances their rapid restoration through central memory T cellsVirological outcome after structured interruption of antiretroviral therapy for human immunodeficiency virus infection is associated with the functional profile of virus-specific CD8+ T cells.
P2860
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P2860
Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection.
description
2005 nî lūn-bûn
@nan
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Characterization of functional ...... tection after HIV-1 infection.
@ast
Characterization of functional ...... tection after HIV-1 infection.
@en
type
label
Characterization of functional ...... tection after HIV-1 infection.
@ast
Characterization of functional ...... tection after HIV-1 infection.
@en
prefLabel
Characterization of functional ...... tection after HIV-1 infection.
@ast
Characterization of functional ...... tection after HIV-1 infection.
@en
P2093
P2860
P50
P356
P1476
Characterization of functional ...... tection after HIV-1 infection.
@en
P2093
Anju Bansal
Barbara Exley
Daniel C Douek
David R Ambrozak
J Michael Kilby
Jim Tartaglia
Kent J Weinhold
Mario Roederer
Michael R Betts
P2860
P304
P356
10.1073/PNAS.0408773102
P407
P577
2005-03-07T00:00:00Z