about
Network of coupled promoting motions in enzyme catalysisSubstrate conformational transitions in the active site of chorismate mutase: their role in the catalytic mechanismThe importance of reactant positioning in enzyme catalysis: a hybrid quantum mechanics/molecular mechanics study of a haloalkane dehalogenaseProtein dynamics and catalysis: the problems of transition state theory and the subtlety of dynamic controlEvolutionarily conserved linkage between enzyme fold, flexibility, and catalysisThe putative catalytic bases have, at most, an accessory role in the mechanism of arginine kinaseCrystal Structure of a Type II Dihydrofolate Reductase Catalytic Ternary Complex †High-Resolution Structure of the Nitrile Reductase QueF Combined with Molecular Simulations Provide Insight into Enzyme MechanismQuantitative Structural Insight into Human Variegate Porphyria DiseaseCharacterization of member of DUF1888 protein family, self-cleaving and self-assembling endopeptidase.Near attack conformers dominate -phosphoglucomutase complexes where geometry and charge distribution reflect those of substrateLong-lived glycosyl-enzyme intermediate mimic produced by formate re-activation of a mutant endoglucanase lacking its catalytic nucleophileCorrelated conformational fluctuations during enzymatic catalysis: Implications for catalytic rate enhancementInvestigations on recyclisation and hydrolysis in avibactam mediated serine β-lactamase inhibitionConvergent Mechanistic Features between the Structurally Diverse N- and O-Methyltransferases: Glycine N-Methyltransferase and Catechol O-Methyltransferase.NDM-1, the ultimate promiscuous enzyme: substrate recognition and catalytic mechanismElectrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis.The active site dynamics of 4-chlorobenzoyl-CoA dehalogenase.Loop residues and catalysis in OMP synthase.Extreme electric fields power catalysis in the active site of ketosteroid isomerasePreorganization and protein dynamics in enzyme catalysis.Convex Arrhenius plots and their interpretationBarrier passage and protein dynamics in enzymatically catalyzed reactions.Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics.Cyclooxygenase 2 selective inhibitors in cancer treatment and prevention.Nuclearity and cooperativity effects in binuclear catalysts and cocatalysts for olefin polymerization.Multidisciplinary experimental approaches to characterizing biomolecular dynamics.Ribozyme speed limits.Mechanisms and free energies of enzymatic reactions.Multidimensional tunneling, recrossing, and the transmission coefficient for enzymatic reactionsCorrelated structural kinetics and retarded solvent dynamics at the metalloprotease active sitePhosphoryl Transfer Reaction Snapshots in Crystals: INSIGHTS INTO THE MECHANISM OF PROTEIN KINASE A CATALYTIC SUBUNIT.ESR spectroscopy identifies inhibitory Cu2+ sites in a DNA-modifying enzyme to reveal determinants of catalytic specificitySearching sequence space: two different approaches to dihydrofolate reductase catalysis.Botulinum neurotoxin structure, engineering, and novel cellular trafficking and targeting.Transition state stabilization by general acid catalysis, water expulsion, and enzyme reorganization in Medicago savita chalcone isomerase.Conserved C-terminal threonine of hepatitis C virus NS3 regulates autoproteolysis and prevents product inhibition.Thermodynamic framework for identifying free energy inventories of enzyme catalytic cycles.Extracting the causality of correlated motions from molecular dynamics simulations.Anticorrelated motions as a driving force in enzyme catalysis: the dehydrogenase reaction.
P2860
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P2860
description
2000 nî lūn-bûn
@nan
2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Chemical basis for enzyme catalysis.
@ast
Chemical basis for enzyme catalysis.
@en
type
label
Chemical basis for enzyme catalysis.
@ast
Chemical basis for enzyme catalysis.
@en
prefLabel
Chemical basis for enzyme catalysis.
@ast
Chemical basis for enzyme catalysis.
@en
P356
P1433
P1476
Chemical basis for enzyme catalysis.
@en
P2093
Benkovic SJ
P304
P356
10.1021/BI0003689
P407
P577
2000-05-01T00:00:00Z