Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics.
about
Computer aided enzyme design and catalytic conceptsAdvances in kinetic isotope effect measurement techniques for enzyme mechanism studyEnzyme structure and dynamics affect hydrogen tunneling: The impact of a remote side chain (I553) in soybean lipoxygenase-1Effects of Cavities at the Nicotinamide Binding Site of Liver Alcohol Dehydrogenase on Structure, Dynamics and CatalysisAt the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?Does the pressure dependence of kinetic isotope effects report usefully on dynamics in enzyme H-transfer reactions?Chemical Ligation and Isotope Labeling to Locate Dynamic Effects during Catalysis by Dihydrofolate ReductasePerspective: Defining and quantifying the role of dynamics in enzyme catalysisLinking protein structure and dynamics to catalysis: the role of hydrogen tunnelling.The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase.Effects of a distal mutation on active site chemistry.Enzymatic transition states and dynamic motion in barrier crossing.On the curvature in logarithmic plots of rate coefficients for chemical reactionsHydrogen tunneling links protein dynamics to enzyme catalysisImportance of protein dynamics during enzymatic C-H bond cleavage catalysis.Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenasesExamining the case for the effect of barrier compression on tunneling, vibrationally enhanced catalysis, catalytic entropy and related issuesTemperature dependence of protein motions in a thermophilic dihydrofolate reductase and its relationship to catalytic efficiencyElusive transition state of alcohol dehydrogenase unveiled.Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid.A computational study of the open and closed forms of the N-lobe human serum transferrin apoprotein.An iron 13S-lipoxygenase with an α-linolenic acid specific hydroperoxidase activity from Fusarium oxysporum.Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase.Isotope effects as probes for enzyme catalyzed hydrogen-transfer reactions.Multidisciplinary experimental approaches to characterizing biomolecular dynamics.Dynamics and dissipation in enzyme catalysisMultiple intermediates, diverse conformations, and cooperative conformational changes underlie the catalytic hydride transfer reaction of dihydrofolate reductase.Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effectsSmall temperature dependence of the kinetic isotope effect for the hydride transfer reaction catalyzed by Escherichia coli dihydrofolate reductase.Multidimensional tunneling, recrossing, and the transmission coefficient for enzymatic reactionsThe copper-enzyme family of dopamine beta-monooxygenase and peptidylglycine alpha-hydroxylating monooxygenase: resolving the chemical pathway for substrate hydroxylation.How an enzyme surmounts the activation energy barrier.Protein-like proton exchange in a synthetic host cavity.Thermal-activated protein mobility and its correlation with catalysis in thermophilic alcohol dehydrogenase.Hydrogen tunnelling in enzyme-catalysed H-transfer reactions: flavoprotein and quinoprotein systems.Gauging the flexibility of the active site in soybean lipoxygenase-1 (SLO-1) through an atom-centered density matrix propagation (ADMP) treatment that facilitates the sampling of rare events.Extended spin-boson model for nonadiabatic hydrogen tunneling in the condensed phase.Mechanistic insights into the bifunctional non-heme iron oxygenase carbapenem synthase by active site saturation mutagenesisIsotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenasesMeasuring specificity in multi-substrate/product systems as a tool to investigate selectivity in vivo.
P2860
Q26866557-6103BA75-BE40-4031-91FE-0AD962FA6DB9Q27005795-1C14C766-CF0B-494B-B5E0-C1A7F7EAFF89Q27649699-D3212CF8-9AE5-4A3A-BECC-5D2080B07CEAQ27681376-3C21359C-79EB-4468-93AD-CE45EC35BC22Q28271287-7D2D3686-6DCB-43B3-8511-FAAC7F4ADF82Q28829786-0B3A98B3-6F9C-4CA7-A9F5-D6C87904ADC6Q28830226-E2663D4E-BB84-4395-B8ED-E00B5EAA724FQ28834243-BD5E0C71-F9E5-467C-A91C-AA8FA2C9BC73Q30355965-F8CDB364-68BC-479E-8D3D-69E2474935CAQ30478319-C370F5AD-32B8-4525-911F-09B7A5464D5FQ30483738-C29E051A-969B-476E-964B-D24F6878A024Q30494227-4C9D1853-F921-45E1-98D6-60C0A690DC53Q30501281-99781A0E-719A-4DF7-A220-C37929C6D23BQ33792054-49711F1D-FBC8-4B20-B42C-FEF1CBFAE400Q33881988-85F589AD-EFA5-403E-87E3-803AE4CF1810Q33903800-5A663154-74C9-4FD1-BC7D-82E1A601CE01Q33917537-2237E9ED-5740-4337-8E8E-72C4A04EB43BQ33933104-293D3D5D-32A6-4794-86ED-2700375EDC83Q34006607-4046EFBC-170E-435A-9160-688B67F26E7FQ34109730-E70508CA-8F52-4608-8A5F-2DDFB73DE20AQ34183823-27B43B64-6FD1-46A4-B2A9-E5933974AFC9Q34761003-512E7728-1D9B-4865-BDF6-959B4E3372BCQ35127441-43B2D70F-2031-4F56-8CCF-DFA37AE5CFFEQ35127653-45C4A1A9-C979-4988-B3D3-C3F6D2E52249Q35173705-0AD666E5-39C7-40A3-9857-AE2A8C84B963Q35239656-4035958D-1C8A-4522-87C0-2C1153202B00Q35383137-1C49CE00-265A-43BA-966D-CBA90DE1A3D7Q35578715-EFF8D5FA-0571-4797-955E-B1CE6F92EE6DQ35765480-6403874E-C07E-44BB-99DC-7E66F0C6C39EQ35774258-0546A96C-D725-4BD8-B089-622B2BE88C3DQ36318859-20006080-9024-4981-8D6F-D8C30A8D2314Q36347286-870EA1DB-F040-4998-BD5F-A92920EB5C7CQ36394268-79C2FDBF-DCFE-4609-B5C3-0929197953D2Q36447788-F22CEC7F-6205-4DA4-8E88-4003B1063FE5Q36549101-0F517BD3-7F36-4B14-B3E6-B2F2025547CCQ36572667-6DE254E4-7B36-48DF-A64A-56830E291634Q36624040-4CD97F71-B319-427C-88A9-D25F3928115DQ36932752-37E767BC-D35B-4B82-A2FA-AB101853FA7FQ36952303-D2D9864C-0131-4AA8-A5EC-0051EB3CBC1CQ37046911-21CA1B69-8E96-438F-AC31-3FF593139EAB
P2860
Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics.
@ast
Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics.
@en
Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics.
@nl
type
label
Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics.
@ast
Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics.
@en
Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics.
@nl
prefLabel
Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics.
@ast
Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics.
@en
Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics.
@nl
P2860
P1433
P1476
Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics.
@en
P2093
Judith P Klinman
Michael J Knapp
P2860
P304
P356
10.1046/J.1432-1033.2002.03022.X
P407
P577
2002-07-01T00:00:00Z