HPV episome levels are potently decreased by pyrrole-imidazole polyamides.
about
Binding studies of a large antiviral polyamide to a natural HPV sequence.Controlling gene networks and cell fate with precision-targeted DNA-binding proteins and small-molecule-based genome readers.Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing.DNA damage repair genes controlling human papillomavirus (HPV) episome levels under conditions of stability and extreme instabilityRecent Insights into the Control of Human Papillomavirus (HPV) Genome Stability, Loss, and Degradation.Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns.Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC (Crosslinking of Small Molecules to Isolate Chromatin)Systematic synthetic and biophysical development of mixed sequence DNA binding agents.Identification of several high-risk HPV inhibitors and drug targets with a novel high-throughput screening assayTargeting human papillomavirus genome replication for antiviral drug discoveryCorrelation of local effects of DNA sequence and position of β-alanine inserts with polyamide-DNA complex binding affinities and kinetics.Synthetic genome readers target clustered binding sites across diverse chromatin states.Design and synthesis of heterocyclic cations for specific DNA recognition: from AT-rich to mixed-base-pair DNA sequencesBinding to the DNA minor groove by heterocyclic dications: from AT-specific monomers to GC recognition with dimers.Programmable DNA-binding small molecules.DNA Binding Polyamides and the Importance of DNA Recognition in their use as Gene-Specific and Antiviral AgentsHuman papillomavirus episome stability is reduced by aphidicolin and controlled by DNA damage response pathways.Interactions of two large antiviral polyamides with the long control region of HPV16.Mapping polyamide-DNA interactions in human cells reveals a new design strategy for effective targeting of genomic sites.Fe(II)/Et3N-Relay-catalyzed domino reaction of isoxazoles with imidazolium salts in the synthesis of methyl 4-imidazolylpyrrole-2-carboxylates, its ylide and betaine derivativesAffinity and kinetic modulation of polyamide-DNA interactions by N-modification of the heterocycles.Fluorescence assay of polyamide-DNA interactions.Improved Antiviral Activity of a Polyamide Against High-Risk Human Papillomavirus Via N-Terminal Guanidinium Substitution.Promoter scanning of the human COX-2 gene with 8-ring polyamides: unexpected weakening of polyamide-DNA binding and selectivity by replacing an internal N-Me-pyrrole with β-alanine.A simple approach to pyrrolylimidazole derivatives by azirine ring expansion with imidazolium ylides.β-Alanine and N-terminal cationic substituents affect polyamide-DNA binding.What is the antiviral potential of pyrrole-imidazole polyamides?Structural basis of DNA duplex distortion induced by thiazole-containing hairpin polyamides.A polyamide inhibits replication of vesicular stomatitis virus by targeting RNA in the nucleocapsid.
P2860
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P2860
HPV episome levels are potently decreased by pyrrole-imidazole polyamides.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
HPV episome levels are potently decreased by pyrrole-imidazole polyamides.
@ast
HPV episome levels are potently decreased by pyrrole-imidazole polyamides.
@en
type
label
HPV episome levels are potently decreased by pyrrole-imidazole polyamides.
@ast
HPV episome levels are potently decreased by pyrrole-imidazole polyamides.
@en
prefLabel
HPV episome levels are potently decreased by pyrrole-imidazole polyamides.
@ast
HPV episome levels are potently decreased by pyrrole-imidazole polyamides.
@en
P2093
P2860
P1433
P1476
HPV episome levels are potently decreased by pyrrole-imidazole polyamides
@en
P2093
Chris Fisher
Kevin J Koeller
Michael Helmus
Terri G Edwards
Urszula Slomczynska
P2860
P304
P356
10.1016/J.ANTIVIRAL.2011.05.014
P577
2011-06-02T00:00:00Z