Efficient screening of cytochrome P450 BM3 mutants for their metabolic activity and diversity toward a wide set of drug-like molecules in chemical space.
about
Optimization of the bacterial cytochrome P450 BM3 system for the production of human drug metabolitesInsights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculationsDrug Oxidation by Cytochrome P450BM3 : Metabolite Synthesis and Discovering New P450 Reaction Types.Application of a Continuous-Flow Bioassay to Investigate the Organic Solvent Tolerability of Cytochrome P450 BM3 Mutants.Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity.Streptomyces cytochromes P450: applications in drug metabolism.Cytochromes P450 as promising catalysts for biotechnological application: chances and limitations.Drug metabolism in microorganisms.Directed evolution of cytochrome P450 enzymes for biocatalysis: exploiting the catalytic versatility of enzymes with relaxed substrate specificity.CYP267A1 and CYP267B1 from Sorangium cellulosum So ce56 are Highly Versatile Drug Metabolizers.P450BM3 fused to phosphite dehydrogenase allows phosphite-driven selective oxidations.Exploring PTDH-P450BM3 Variants for the Synthesis of Drug Metabolites.Molecular Determinants of Substrate Affinity and Enzyme Activity of a Cytochrome P450 Variant
P2860
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P2860
Efficient screening of cytochrome P450 BM3 mutants for their metabolic activity and diversity toward a wide set of drug-like molecules in chemical space.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Efficient screening of cytochr ...... e molecules in chemical space.
@ast
Efficient screening of cytochr ...... e molecules in chemical space.
@en
type
label
Efficient screening of cytochr ...... e molecules in chemical space.
@ast
Efficient screening of cytochr ...... e molecules in chemical space.
@en
prefLabel
Efficient screening of cytochr ...... e molecules in chemical space.
@ast
Efficient screening of cytochr ...... e molecules in chemical space.
@en
P2093
P356
P1476
Efficient screening of cytochr ...... e molecules in chemical space.
@en
P2093
Caroline J Decker
Jan N M Commandeur
Jelle Reinen
John Saunders
Jolanda S van Leeuwen
Lifang Sun
Nico P E Vermeulen
Peter D J Grootenhuis
Yongmin Li
P304
P356
10.1124/DMD.111.039461
P577
2011-06-14T00:00:00Z