Borrelidin, a small molecule nitrile-containing macrolide inhibitor of threonyl-tRNA synthetase, is a potent inducer of apoptosis in acute lymphoblastic leukemia.
about
A genomic and evolutionary approach reveals non-genetic drug resistance in malariaExtracellular matrix as target for antitumor therapyStructural basis for full-spectrum inhibition of translational functions on a tRNA synthetaseAminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor.Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism.Insights into the preclinical treatment of blood-stage malaria by the antibiotic borrelidin.Genetic validation of aminoacyl-tRNA synthetases as drug targets in Trypanosoma brucei.New functions of protein kinase Gcn2 in yeast and mammals.Metabolic control of tumour progression and antitumour immunityPotential therapeutic targets and small molecular drugs for pediatric B-precursor acute lymphoblastic leukemia treatment based on microarray dataFerrichrome identified from Lactobacillus casei ATCC334 induces apoptosis through its iron-binding site in gastric cancer cells.Targeting mitosis-regulating genes in cisplatin-sensitive and -resistant melanoma cells: A live-cell RNAi screen displays differential nucleus-derived phenotypes.Borrelidin has limited anti-cancer effects in bcl-2 overexpressing breast cancer and leukemia cells and reveals toxicity in non-malignant breast epithelial cells.Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis.Alternative Splicing as a Target for Cancer Treatment.
P2860
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P2860
Borrelidin, a small molecule nitrile-containing macrolide inhibitor of threonyl-tRNA synthetase, is a potent inducer of apoptosis in acute lymphoblastic leukemia.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Borrelidin, a small molecule n ...... acute lymphoblastic leukemia.
@ast
Borrelidin, a small molecule n ...... acute lymphoblastic leukemia.
@en
type
label
Borrelidin, a small molecule n ...... acute lymphoblastic leukemia.
@ast
Borrelidin, a small molecule n ...... acute lymphoblastic leukemia.
@en
prefLabel
Borrelidin, a small molecule n ...... acute lymphoblastic leukemia.
@ast
Borrelidin, a small molecule n ...... acute lymphoblastic leukemia.
@en
P2093
P2860
P1476
Borrelidin, a small molecule n ...... acute lymphoblastic leukemia.
@en
P2093
Andrew P Weng
Aziz Ghahary
Christopher J Ong
Darya Habibi
Nadya Ogloff
Reza B Jalili
P2860
P2888
P304
P356
10.1007/S10637-011-9700-Y
P577
2011-06-17T00:00:00Z
P6179
1024727925