Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss. - Wikidata - wikimedia - TriplyDB

Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.

Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.

http://www.wikidata.org/entity/Q33677433

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The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia Focused chemical genomics using zebrafish xenotransplantation as a pre-clinical therapeutic platform for T-cell acute lymphoblastic leukemia Borrelidin, a small molecule nitrile-containing macrolide inhibitor of threonyl-tRNA synthetase, is a potent inducer of apoptosis in acute lymphoblastic leukemia.Zebrafish screen identifies novel compound with selective toxicity against leukemia.Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment.Notch is oncogenic dominant in T-cell acute lymphoblastic leukemia.High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling.Notch Signaling in T-Cell Development and T-ALL Human cancer growth and therapy in immunodeficient mouse models.IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression.Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL.Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia.The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia.Defined, serum-free conditions for in vitro culture of primary human T-ALL blasts.Convergence of the ZMIZ1 and NOTCH1 pathways at C-MYC in acute T lymphoblastic leukemias.TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia The NOTCH signaling pathway: role in the pathogenesis of T-cell acute lymphoblastic leukemia and implication for therapy.NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia.NOTCH and phosphatidylinositide 3-kinase/phosphatase and tensin homolog deleted on chromosome ten/AKT/mammalian target of rapamycin (mTOR) signaling in T-cell development and T-cell acute lymphoblastic leukemia.Therapeutic potential of Notch inhibition in T-cell acute lymphoblastic leukemia: rationale, caveats and promises.Oncogenic PTEN functions and models in T-cell malignancies.Stability of patient-specific features of altered DNA replication timing in xenografts of primary human acute lymphoblastic leukemia.Microenvironmental cues for T-cell acute lymphoblastic leukemia development.Oncogenic Notch signaling in T-cell and B-cell lymphoproliferative disorders.Differential effects of polyphenols on proliferation and apoptosis in human myeloid and lymphoid leukemia cell lines.Collaborating Pathways that Functionally Amplify NOTCH1 Signals in T-Cell Acute Lymphoblastic Leukemia.Synergistic effects of interleukin-7 and pre-T cell receptor signaling in human T cell development.The homeoprotein Dlx5 drives murine T-cell lymphomagenesis by directly transactivating Notch and upregulating Akt signaling.Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.PI3Kγ/δ and NOTCH1 Cross-Regulate Pathways That Define the T-cell Acute Lymphoblastic Leukemia Disease Signature.Regulation of PI3K signaling in T-cell acute lymphoblastic leukemia: a novel PTEN/Ikaros/miR-26b mechanism reveals a critical targetable role for PIK3CD.Discovery of biologically active oncologic and immunologic small molecule therapies using zebrafish: overview and example of modulation of T cell activation.

P2860

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P2860

Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.

http://www.wikidata.org/entity/Q33677433

description

2009 nî lūn-bûn

@nan

2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Acute T-cell leukemias remain ...... spite PTEN and INK4A/ARF loss.

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Acute T-cell leukemias remain ...... spite PTEN and INK4A/ARF loss.

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Acute T-cell leukemias remain ...... spite PTEN and INK4A/ARF loss.

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Acute T-cell leukemias remain ...... spite PTEN and INK4A/ARF loss.

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Acute T-cell leukemias remain ...... spite PTEN and INK4A/ARF loss.

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Acute T-cell leukemias remain ...... spite PTEN and INK4A/ARF loss.

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Acute T-cell leukemias remain ...... espite PTEN and INK4A/ARF loss

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Amanda Larson Gedman

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Andrew P Weng

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Florence Armstrong

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Larry H Matherly

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Mingjian James You

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Qing Liu

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Samuel Gusscott

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Xiuhua Gao

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P2860

Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1

Transcriptional analysis of the PTEN/MMAC1 pseudogene, psiPTEN

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

Pten is essential for embryonic development and tumour suppression

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

Inducible gene targeting in mice

Plat-E: an efficient and stable system for transient packaging of retroviruses

PI3K pathway alterations in cancer: variations on a theme

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Francoise Pflumio

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