Effects of metabotropic glutamate receptor 2/3 agonism and antagonism on schizophrenia-like cognitive deficits induced by phencyclidine in rats.

Effects of metabotropic glutamate receptor 2/3 agonism and antagonism on schizophrenia-like cognitive deficits induced by phencyclidine in rats.

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http://www.wikidata.org/entity/Q33936354
CNTRICS final animal model task selection: control of attentionTargeting metabotropic glutamate receptors for novel treatments of schizophrenia.The metabotropic glutamate 2/3 receptor agonist LY379268 counteracted ketamine-and apomorphine-induced performance deficits in the object recognition task, but not object location task, in rats.mGluR2/3 agonist LY379268 rescues NMDA and GABAA receptor level deficits induced in a two-hit mouse model of schizophrenia.Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons.Pharmacogenetic associations of the type-3 metabotropic glutamate receptor (GRM3) gene with working memory and clinical symptom response to antipsychotics in first-episode schizophreniaRepeated phencyclidine administration alters glutamate release and decreases GABA markers in the prefrontal cortex of ratsComparative effects of different test day challenges on performance in the 5-choice serial reaction time task.Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice.Metabotropic glutamate receptors as therapeutic targets for schizophrenia.Fractionation of spatial memory in GRM2/3 (mGlu2/mGlu3) double knockout mice reveals a role for group II metabotropic glutamate receptors at the interface between arousal and cognition.The antipsychotic-like effects of the mGlu group III orthosteric agonist, LSP1-2111, involves 5-HT₁A signalling.Altered object exploration but not temporal order memory retrieval in an object recognition test following treatment of rats with the group II metabotropic glutamate receptor agonist LY379268.Pre-treatment with the mGlu2/3 receptor agonist LY379268 attenuates DOI-induced impulsive responding and regional c-Fos protein expression.Interaction of mGlu2/3 agonism with clozapine and lurasidone to restore novel object recognition in subchronic phencyclidine-treated rats.
P2860

Effects of metabotropic glutamate receptor 2/3 agonism and antagonism on schizophrenia-like cognitive deficits induced by phencyclidine in rats.

Item
http://www.wikidata.org/entity/Q33936354
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
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2010年論文
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2010年論文
@zh-hk
2010年論文
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2010年論文
@zh-tw
2010年论文
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name
Effects of metabotropic glutam ...... uced by phencyclidine in rats.
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Effects of metabotropic glutam ...... uced by phencyclidine in rats.
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Effects of metabotropic glutam ...... uced by phencyclidine in rats.
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Effects of metabotropic glutam ...... uced by phencyclidine in rats.
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Effects of metabotropic glutam ...... uced by phencyclidine in rats.
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Effects of metabotropic glutam ...... uced by phencyclidine in rats.
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Effects of metabotropic glutam ...... uced by phencyclidine in rats.
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P2093
P2860
P304
P31
P356
10.1016/J.EJPHAR.2009.12.040
P407
P433
P478
P577
P5875
P698
P921
P932