A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis
about
Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicingHuman helicase gene SKI2W in the HLA class III region exhibits striking structural similarities to the yeast antiviral gene SKI2 and to the human gene KIAA0052: emergence of a new gene familyHuman homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicingThe human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitroThe HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicasesPRP16, a DEAH-box RNA helicase, is recruited to the spliceosome primarily via its nonconserved N-terminal domainIdentification of an RNA-dependent ATPase activity in mammalian U5 snRNPsA novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reactionCloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43Functional roles of DExD/H-box RNA helicases in Pre-mRNA splicingRNA helicases in splicingSplicing fidelity: DEAD/H-box ATPases as molecular clocksStructural basis for the function of DEAH helicasesCrystal structure of the functional domain of the splicing factor Prp18Visualizing Group II Intron Catalysis through the Stages of SplicingCryo-EM structure of the spliceosome immediately after branchingElevated levels of a U4/U6.U5 snRNP-associated protein, Spp381p, rescue a mutant defective in spliceosome maturation.How Slu7 and Prp18 cooperate in the second step of yeast pre-mRNA splicing.The splicing factor PRP2, a putative RNA helicase, interacts directly with pre-mRNASpliceosome activation by PRP2 ATPase prior to the first transesterification reaction of pre-mRNA splicingMutational analysis identifies two separable roles of the Saccharomyces cerevisiae splicing factor Prp18.The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome.A novel splicing factor, Yju2, is associated with NTC and acts after Prp2 in promoting the first catalytic reaction of pre-mRNA splicing.Synthetic lethality of yeast slt mutations with U2 small nuclear RNA mutations suggests functional interactions between U2 and U5 snRNPs that are important for both steps of pre-mRNA splicing.Progression through the spliceosome cycle requires Prp38p function for U4/U6 snRNA dissociationDbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export.Spatial organization of protein-RNA interactions in the branch site-3' splice site region during pre-mRNA splicing in yeast.Prp22, a DExH-box RNA helicase, plays two distinct roles in yeast pre-mRNA splicingThe Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing.Functional interactions between Prp8, Prp18, Slu7, and U5 snRNA during the second step of pre-mRNA splicing.Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.The DEAH-box protein PRP22 is an ATPase that mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes.Functional association of essential splicing factor(s) with PRP19 in a protein complex.The carboxy terminal WD domain of the pre-mRNA splicing factor Prp17p is critical for function.Molecular dissection of step 2 catalysis of yeast pre-mRNA splicing investigated in a purified system.The 1997 Thomas Hunt Morgan Medal. Oliver Evans Nelson, JrThe ATP requirement for U2 snRNP addition is linked to the pre-mRNA region 5' to the branch site.Biased Brownian ratcheting leads to pre-mRNA remodeling and capture prior to first-step splicing.Genetic and functional interaction of evolutionarily conserved regions of the Prp18 protein and the U5 snRNA.ATP requirement for Prp5p function is determined by Cus2p and the structure of U2 small nuclear RNA.
P2860
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P2860
A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis
description
1992 nî lūn-bûn
@nan
1992 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
A conformational rearrangement ...... nt on PRP16 and ATP hydrolysis
@ast
A conformational rearrangement ...... nt on PRP16 and ATP hydrolysis
@en
type
label
A conformational rearrangement ...... nt on PRP16 and ATP hydrolysis
@ast
A conformational rearrangement ...... nt on PRP16 and ATP hydrolysis
@en
prefLabel
A conformational rearrangement ...... nt on PRP16 and ATP hydrolysis
@ast
A conformational rearrangement ...... nt on PRP16 and ATP hydrolysis
@en
P2860
P1433
P1476
A conformational rearrangement ...... nt on PRP16 and ATP hydrolysis
@en
P2093
P2860
P304
P407
P577
1992-12-01T00:00:00Z