Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression. - Wikidata - wikimedia - TriplyDB

Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression.

Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression.

http://www.wikidata.org/entity/Q33944717

about

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.PTEN function: how normal cells control it and tumour cells lose it Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation No evidence for involvement of SDHD in neuroblastoma pathogenesis Pten dose dictates cancer progression in the prostate Phosphoinositides: tiny lipids with giant impact on cell regulation Genetically engineered mouse models of prostate cancer FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome.HCV infection-associated hepatocellular carcinoma in humanized mice Regulation of PTEN stability and activity by Plk3 Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma Pooled analysis of loss of heterozygosity in breast cancer: a genome scan provides comparative evidence for multiple tumor suppressors and identifies novel candidate regions.Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten Molecular genetics of human prostate cancer.Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouse Deregulation of FoxO3a accelerates prostate cancer progression in TRAMP mice Androgen receptor targets NFkappaB and TSP1 to suppress prostate tumor growth in vivo.Simultaneous haploinsufficiency of Pten and Trp53 tumor suppressor genes accelerates tumorigenesis in a mouse model of prostate cancer.p27(Kip1) deficiency promotes prostate carcinogenesis but does not affect the efficacy of retinoids in suppressing the neoplastic process.Loss of the SSeCKS/Gravin/AKAP12 gene results in prostatic hyperplasia 3'UTR shortening identifies high-risk cancers with targeted dysregulation of the ceRNA network.The aryl hydrocarbon receptor (AhR) inhibits vanadate-induced vascular endothelial growth factor (VEGF) production in TRAMP prostates Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis.Role of SV40 integration site at chromosomal interval 1q21.1 in immortalized CRL2504 cells.Prostate cancer-specific and potent antitumor effect of a DD3-controlled oncolytic virus harboring the PTEN gene.The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms.Impaired Pten expression in human malignant peripheral nerve sheath tumours.Reduction of Pten dose leads to neoplastic development in multiple organs of Pten (shRNA) mice Prostate adenocarcinoma: cellular and molecular abnormalities.Emerging targets in the AKT pathway for treatment of androgen-independent prostatic adenocarcinoma.A Drosophila model of multiple endocrine neoplasia type 2.p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control.Combined image and genomic analysis of high-grade serous ovarian cancer reveals PTEN loss as a common driver event and prognostic classifier FISH analysis of PTEN in endometrial carcinoma. Comparison with SNP arrays and MLPA.Comparison of chromosomal and array-based comparative genomic hybridization for the detection of genomic imbalances in primary prostate carcinomas.PTEN: Multiple Functions in Human Malignant Tumors Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice.PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability

P2860

Q24292919-69B21DF8-A28D-4568-A772-314FEB9077E3 Q24299543-775DEAD8-52CF-4FC9-916C-4E4347AABFED Q24528114-9AB1F8CA-C31B-47F1-AB20-3219B1566E31 Q24673801-8C669B0A-673D-4182-A90A-435783BB2A61 Q24791722-F1D5ECFC-4AE2-4FA2-8FE8-5EB10AB2E978 Q24791909-CE92F89F-C3E0-4110-848F-D9B337CD5F3D Q27012953-B4666793-883B-43DA-9FE7-1CC8C9E25005 Q27026768-EABEF85A-7DAF-4242-92C6-DFD4C7DBB648 Q27851411-C93FFB53-337F-47CA-88E4-56407933771A Q28384465-96D4F287-CEA6-4152-94CA-0398A3CBC352 Q28512686-6A1EE23A-8B12-4E9D-8DE9-E69D0396FFDD Q30278895-F58CE2CF-6B65-408F-BA46-68BA77DD73FA Q30476046-7E30174A-9745-4C0C-9867-FCFA70D89B47 Q30524175-0DB3BF61-8250-4C1F-8A02-BACB8178838F Q31039228-3C8C7B5E-E401-4F8C-A095-770F2ABBFA27 Q33194830-47513740-B9A6-4A30-9208-C7062D9CEBBC Q33601298-58E183ED-D62E-4A5A-A510-272B46BBD50B Q33607836-DCFD1FDB-0BF5-45F1-9269-14DE7AACFAA5 Q33687282-19D906D5-3886-4F01-80E3-5DACBEB6AFDC Q33713330-AE702E73-5F37-4807-A7C3-87D62CD78FE3 Q33730212-42F7A221-350B-4B4B-A20C-6EE95428C6CD Q33788981-C5CFC92A-2721-48F7-B2D6-9B9197B1C2F0 Q33986252-D3F9C8DD-0580-4D11-98C2-2358849BF393 Q34014956-F3534E29-AE45-43E7-AA8A-BDA1C1198B6F Q34035772-D600D441-5F2A-4A35-B3A5-9D91E47484D1 Q34235604-AB14F36A-BBCC-41D1-80F1-27FEBB818D7C Q34244242-4EED6EC7-43EA-4754-BDDC-999712D92C9D Q34471826-E1623AC8-50AD-4689-B766-0FD8F5E7B179 Q34479331-DC7EB350-4A06-49F5-8923-6E0D4AE268EC Q34504232-1312D4E2-92F9-40D4-AB17-B8647EA58C2A Q34568941-42C0B6B5-BE6D-4857-929A-ADAE310CAAC5 Q34589821-C2BB701A-2F6C-4C61-B5E6-1416018BC54C Q34718105-B30F79C8-0E9A-49E6-9C9A-4436EA4258EA Q34720998-94977F6E-4B5B-437E-9663-F45D4B7BF02A Q34805622-6C4B60FD-6B16-44CC-AEE6-8BB11384E046 Q35039874-06CB3FBD-90B3-4E9B-BDB5-560E27965726 Q35087328-072AC27C-6458-4B67-BC06-88F418111AC4 Q35192607-731D0F9B-9CEC-4029-98EB-62DFCDCD030D Q35260766-F1019B42-D323-4AA2-BEBB-02FE52F3E2AC Q35275603-FE7C2C39-3CDF-435E-AB9C-13F0CEA50E8B

P2860

Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression.

http://www.wikidata.org/entity/Q33944717

description

2001 nî lūn-bûn

@nan

2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2001年の論文

@ja

2001年論文

@yue

2001年論文

@zh-hant

2001年論文

@zh-hk

2001年論文

@zh-mo

2001年論文

@zh-tw

2001年论文

@wuu

name

Haploinsufficiency of the Pten ...... s prostate cancer progression.

@ast

Haploinsufficiency of the Pten ...... s prostate cancer progression.

@en

type

label

Haploinsufficiency of the Pten ...... s prostate cancer progression.

@ast

Haploinsufficiency of the Pten ...... s prostate cancer progression.

@en

prefLabel

Haploinsufficiency of the Pten ...... s prostate cancer progression.

@ast

Haploinsufficiency of the Pten ...... s prostate cancer progression.

@en

P1433

Q33944717-49647D1D-92E5-4A92-96C7-79405CA6A2D1

P1476

Q33944717-5ED561A0-F604-4C13-844C-F962F465A2A9

P2093

Q33944717-23F2CA32-1F80-42DB-BDE1-87F812AE89FB

Q33944717-2A5FC3EB-C9FA-481E-ADC4-6D46F4AA26B9

Q33944717-9CDF00B8-3B84-4434-A75A-4A35A04584FD

Q33944717-C2987A36-CE31-4881-AC5F-E51D116D84A4

Q33944717-CBED4006-B9D6-4AD2-8859-B6F4DE5D0E2F

Q33944717-F448D2A5-8AC1-498C-9F97-5B242F0CD9CB

Q33944717-FCF21213-20A2-4956-8E40-85A95C555CF6

P2860

Q33944717-050090C7-FA60-4C0E-ABC1-88181B3548A6

Q33944717-0787A536-524A-492E-AC39-11936BF9D49D

Q33944717-1E271D24-7882-4E8B-9F0B-05FCBDBC9C9F

Q33944717-1F84002D-F1D1-4B2C-BC53-54D54109A7E1

Q33944717-28DAB11E-B2AD-4EE8-A6C6-9DD4C3B7731D

Q33944717-3A03F571-228A-4FD4-9D51-446AB866CD3D

Q33944717-3AB321E5-38FD-4565-8637-B46B911740D9

Q33944717-3E1C6371-247D-47A2-AC7D-85C3633D28E7

Q33944717-3FA49297-6797-4474-9D4A-0094BB7376F3

Q33944717-61B1587A-6AD4-4C7B-A9B4-7F0EA4EAE772

P304

Q33944717-CFA9D166-7A81-4D70-A010-ACB4354D5A3E

P31

Q33944717-B976AC4A-CAE7-496D-A541-2C4627781850

P356

Q33944717-E9C27E9A-60B8-40A5-898A-C69441F9877C

P407

Q33944717-02B31A8C-1799-46A6-8CCA-8EBC036E992A

P433

Q33944717-529B8171-7B0B-49C9-84F9-5ADFC5162F36

P478

Q33944717-E5C8B879-D637-4084-9BDE-3097C1827719

P577

Q33944717-F6285007-C8B5-40B8-9C4C-AB74CBA23251

P5875

Q33944717-A18E3E44-DA32-4868-8E45-3004592C257F

P698

Q33944717-DD244172-0F35-48D3-9E1D-CCD8CA983E36

P921

Q33944717-34CA3C05-B9A1-44BC-BB68-65571DE670BC

P932

Q33944717-0CAA6F39-AF31-47CA-AFEB-B4ABF20BB6D1

P356

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Haploinsufficiency of the Pten ...... s prostate cancer progression.

@en

P2093

B Kwabi-Addo

http://www.w3.org/2001/XMLSchema#string

D Giri

http://www.w3.org/2001/XMLSchema#string

K Podsypanina

http://www.w3.org/2001/XMLSchema#string

K Schmidt

http://www.w3.org/2001/XMLSchema#string

M Ittmann

http://www.w3.org/2001/XMLSchema#string

N Greenberg

http://www.w3.org/2001/XMLSchema#string

R Parsons

http://www.w3.org/2001/XMLSchema#string

P2860

Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

FGF9 is an autocrine and paracrine prostatic growth factor expressed by prostatic stromal cells

MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

Pten is essential for embryonic development and tumour suppression

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics

P304

11563-11568

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.201167798

http://www.w3.org/2001/XMLSchema#string

P407

P433

20

http://www.w3.org/2001/XMLSchema#string

P478

98

http://www.w3.org/2001/XMLSchema#string

P577

2001-09-11T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

11793501

http://www.w3.org/2001/XMLSchema#string

P698

11553783

http://www.w3.org/2001/XMLSchema#string

P921

haploinsufficiency

P932

58769

http://www.w3.org/2001/XMLSchema#string