Crystal structure of dihydrofolate reductase from Plasmodium vivax: pyrimethamine displacement linked with mutation-induced resistance.
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Crystal Structure of Bacillus anthracis Dihydrofolate Reductase with the Dihydrophthalazine-Based Trimethoprim Derivative RAB1 Provides a Structural Explanation of Potency and SelectivityCombined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to CycloguanilTargeting purine and pyrimidine metabolism in human apicomplexan parasitesWISDOM-II: screening against multiple targets implicated in malaria using computational grid infrastructures.Crystal structure of β-hexosaminidase B in complex with pyrimethamine, a potential pharmacological chaperoneDifferent allele prevalence in the dihydrofolate reductase and dihydropteroate synthase genes in Plasmodium vivax populations from ChinaHierarchical virtual screening for the discovery of new molecular scaffolds in antibacterial hit identificationEvaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening.Reduced impact of pyrimethamine drug pressure on Plasmodium malariae dihydrofolate reductase gene.Drug resistance associated genetic polymorphisms in Plasmodium falciparum and Plasmodium vivax collected in Honduras, Central America.Crystal structure of 4,6-di-amino-2,2-dimethyl-3-[3-(2,4,5-tri-chloro-phen-oxy)prop-oxy]-2,3-di-hydro-1,3,5-triazin-1-ium chloride methanol monosolvate.Modeling the evolution of drug resistance in malariaAnti-folate combination therapies and their effect on the development of drug resistance in Plasmodium vivaxMutations of pvdhfr and pvdhps genes in vivax endemic-malaria areas in Kota Marudu and Kalabakan, SabahFolate metabolism as a source of molecular targets for antimalarials.Structure-activity relationship and comparative docking studies for cycloguanil analogs as PfDHFR-TS inhibitors.Advances in quantitative structure-activity relationship models of antimalarials.Chaperone therapy for GM2 gangliosidosis: effects of pyrimethamine on β-hexosaminidase activity in Sandhoff fibroblasts.Computational analysis of binding between malarial dihydrofolate reductases and anti-folates.Geographic distribution of amino acid mutations in DHFR and DHPS in Plasmodium vivax isolates from Lao PDR, India and Colombia.Pharmacoinformatic Study on the Selective Inhibition of the Protozoan Dihydrofolate Reductase Enzymes.Distribution of Mutations Associated with Antifolate and Chloroquine Resistance among Imported Plasmodium vivax in the State of Qatar.Defining the role of mutations in Plasmodium vivax dihydrofolate reductase-thymidylate synthase gene using an episomal Plasmodium falciparum transfection system.How mutational epistasis impairs predictability in protein evolution and designAccessible mutational trajectories for the evolution of pyrimethamine resistance in the malaria parasite Plasmodium vivax.Plasmodium dihydrofolate reductase is a second enzyme target for the antimalarial action of triclosan.Homology modeling of dihydrofolate reductase from T. gondii bonded to antagonists: molecular docking and molecular dynamics simulations.One barbiturate and two solvated thiobarbiturates containing the triply hydrogen-bonded ADA/DAD synthon, plus one ansolvate and three solvates of their coformer 2,4-diaminopyrimidine.
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P2860
Crystal structure of dihydrofolate reductase from Plasmodium vivax: pyrimethamine displacement linked with mutation-induced resistance.
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Crystal structure of dihydrofo ...... h mutation-induced resistance.
@ast
Crystal structure of dihydrofo ...... h mutation-induced resistance.
@en
type
label
Crystal structure of dihydrofo ...... h mutation-induced resistance.
@ast
Crystal structure of dihydrofo ...... h mutation-induced resistance.
@en
prefLabel
Crystal structure of dihydrofo ...... h mutation-induced resistance.
@ast
Crystal structure of dihydrofo ...... h mutation-induced resistance.
@en
P2093
P2860
P356
P1476
Crystal structure of dihydrofo ...... h mutation-induced resistance.
@en
P2093
Bongkoch Tarnchompoo
Palangpon Kongsaeree
Penchit Chitnumsub
Puttapol Khongsuk
Ubolsree Leartsakulpanich
P2860
P304
13046-13051
P356
10.1073/PNAS.0501747102
P407
P577
2005-08-31T00:00:00Z