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Distinct biochemical properties of human serine hydroxymethyltransferase compared with the Plasmodium enzyme: implications for selective inhibitionInsights into antifolate resistance from malarial DHFR-TS structuresCombined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to CycloguanilCharacterization of Plasmodium falciparum serine hydroxymethyltransferase-A potential antimalarial targetTarget guided synthesis of 5-benzyl-2,4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparumA genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolatesInducible knockdown of Plasmodium gene expression using the glmS ribozymeMolecular characterization of Plasmodium falciparum Bruno/CELF RNA binding proteinsBiochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase IConflicting requirements of Plasmodium falciparum dihydrofolate reductase mutations conferring resistance to pyrimethamine-WR99210 combination.Synthesis of solution-phase combinatorial library of 4,6-diamino-1,2-dihydro-1,3,5-triazine and identification of new leads against A16V+S108T mutant dihydrofolate reductase of Plasmodium falciparum.Stoichiometric selection of tight-binding inhibitors by wild-type and mutant forms of malarial (Plasmodium falciparum) dihydrofolate reductase.A simple dual selection for functionally active mutants of Plasmodium falciparum dihydrofolate reductase with improved solubility.Immobilization of malarial (Plasmodium falciparum) dihydrofolate reductase for the selection of tight-binding inhibitors from combinatorial library.The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities.Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei modelCrystal structure of dihydrofolate reductase from Plasmodium vivax: pyrimethamine displacement linked with mutation-induced resistance.Possible modes of action of the artemisinin-type compounds.Structures of Plasmodium vivax serine hydroxymethyltransferase: implications for ligand-binding specificity and functional control.Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.Kinetic mechanism and the rate-limiting step of Plasmodium vivax serine hydroxymethyltransferase.Estimating mRNA lengths from Plasmodium falciparum genes by Virtual Northern RNA-seq analysis.Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase.Folate metabolism as a source of molecular targets for antimalarials.Role of Plasmodium vivax Dihydropteroate Synthase Polymorphisms in Sulfa Drug Resistance.Crystallization and preliminary crystallographic studies of dihydrofolate reductase-thymidylate synthase from Trypanosoma cruzi, the Chagas disease pathogen.Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu).Decreased sensitivity of artesunate and chloroquine of Plasmodium falciparum infecting hemoglobin H and/or hemoglobin constant spring erythrocytes.Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene.Resistance to artemisinin of malaria parasites (Plasmodium falciparum) infecting alpha-thalassemic erythrocytes in vitro. Competition in drug accumulation with uninfected erythrocytes.pH-dependence and structure-activity relationships in the papain-catalysed hydrolysis of anilides.Basis for antifolate action and resistance in malaria.Mutational analysis of Plasmodium falciparum dihydrofolate reductase: the role of aspartate 54 and phenylalanine 223 on catalytic activity and antifolate binding.Effect of N-terminal truncation of Plasmodium falciparum dihydrofolate reductase on dihydrofolate reductase and thymidylate synthase activity.Characterization, crystallization and preliminary X-ray analysis of bifunctional dihydrofolate reductase-thymidylate synthase from Plasmodium falciparum.Heterogeneity in filterability of erythrocytes from malaria (Plasmodium berghei)-infected blood.Avian influenza A/H5N1 neuraminidase expressed in yeast with a functional head domain.Serine hydroxymethyltransferase from Plasmodium vivax is different in substrate specificity from its homologues.Application of loop-mediated isothermal amplification assay combined with lateral flow dipstick for detection of Plasmodium falciparum and Plasmodium vivax.
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P50
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researcher
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wetenschapper
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հետազոտող
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Y Yuthavong
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Y Yuthavong
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Y Yuthavong
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Y Yuthavong
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Y Yuthavong
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Y Yuthavong
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Y Yuthavong
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Y Yuthavong
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Y Yuthavong
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Y Yuthavong
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Y Yuthavong
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Y Yuthavong
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P106
P1153
7005468673
P31
P496
0000-0002-3582-8401