Heat shock protein 70 (hsp70) as an emerging drug target. - Wikidata - wikimedia - TriplyDB

Heat shock protein 70 (hsp70) as an emerging drug target.

Heat shock protein 70 (hsp70) as an emerging drug target.

http://www.wikidata.org/entity/Q33956906

about

Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells Stress-induced localization of HSPA6 (HSP70B') and HSPA1A (HSP70-1) proteins to centrioles in human neuronal cells Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction Networks Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis Glial Hsp70 protects K+ homeostasis in the Drosophila brain during repetitive anoxic depolarization Molecular mechanism of allosteric communication in Hsp70 revealed by molecular dynamics simulations The human HSP70 family of chaperones: where do we stand?Transcriptome Analysis of the Intracellular Facultative Pathogen Piscirickettsia salmonis: Expression of Putative Groups of Genes Associated with Virulence and Iron Metabolism Exploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome--clozapine-induced agranulocytosis as a case study Identification of key hinge residues important for nucleotide-dependent allostery in E. coli Hsp70/DnaK DnaK as Antibiotic Target: Hot Spot Residues Analysis for Differential Inhibition of the Bacterial Protein in Comparison with the Human HSP70 Investigating Apoptozole as a Chemical Probe for HSP70 Inhibition HSP70 protein promotes survival of C6 and U87 glioma cells by inhibition of ATF5 degradation ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro Transportable, Chemical Genetic Methodology for the Small Molecule-Mediated Inhibition of Heat Shock Factor 1 Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma HSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.Heat shock protein-mediated protection against Cisplatin-induced hair cell death.Inner ear supporting cells protect hair cells by secreting HSP70.Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism Natural products as chemical probes Expression proteomics study to determine metallodrug targets and optimal drug combinations.14-3-3σ induces heat shock protein 70 expression in hepatocellular carcinoma.Anti-leukemia activity of a Hsp70 inhibitor and its hybrid molecules Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators.Expression of a malarial Hsp70 improves defects in chaperone-dependent activities in ssa1 mutant yeast.Protein chaperones: a composition of matter review (2008 - 2013).Phage display biopanning identifies the translation initiation and elongation factors (IF1α-3 and eIF-3) as components of Hsp70-peptide complexes in breast tumour cells.Gene therapy with mitochondrial heat shock protein 70 suppresses visual loss and optic atrophy in experimental autoimmune encephalomyelitis.Quantitative proteomics reveals that Hsp90 inhibition preferentially targets kinases and the DNA damage response.Acute exposure of apigenin induces hepatotoxicity in Swiss mice.Hsp70 and its molecular role in nervous system diseases A chaperone trap contributes to the onset of cystic fibrosis.Activation of the stress proteome as a mechanism for small molecule therapeutics.Differential proteomics and functional research following gene therapy in a mouse model of Leber congenital amaurosis

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Heat shock protein 70 (hsp70) as an emerging drug target.

http://www.wikidata.org/entity/Q33956906

description

2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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name

Heat shock protein 70 (hsp70) as an emerging drug target.

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Heat shock protein 70 (hsp70) as an emerging drug target.

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Heat shock protein 70 (hsp70) as an emerging drug target.

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Heat shock protein 70 (hsp70) as an emerging drug target.

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Heat shock protein 70 (hsp70) as an emerging drug target.

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Heat shock protein 70 (hsp70) as an emerging drug target.

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Heat shock protein 70 (hsp70) as an emerging drug target

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Christopher G Evans

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Jason E Gestwicki

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P2860

Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions.

Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation

The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

HSP70 protects BCL2L12 and BCL2L12A from N-terminal ubiquitination-mediated proteasomal degradation

Short peptides derived from the BAG-1 C-terminus inhibit the interaction between BAG-1 and HSC70 and decrease breast cancer cell growth

A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins

The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis

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