Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors.
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STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasisLeptin-Induced JAK/STAT Signaling and Cancer GrowthOncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cellsThe consequences of selective inhibition of signal transducer and activator of transcription 3 (STAT3) tyrosine705 phosphorylation by phosphopeptide mimetic prodrugs targeting the Src homology 2 (SH2) domainSTAT3: A Novel Molecular Mediator of Resistance to ChemoradiotherapySTAT3 inhibitors for cancer therapy: Have all roads been explored?Leptin signaling molecular actions and drug target in hepatocellular carcinomaDevelopment of new N-Arylbenzamides as STAT3 Dimerization Inhibitors.Phase I Study of OPB-31121, an Oral STAT3 Inhibitor, in Patients with Advanced Solid TumorsIdentification of potent small-molecule inhibitors of STAT3 with anti-inflammatory properties in RAW 264.7 macrophages.mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in miceTh2 differentiation is necessary for soft tissue fibrosis and lymphatic dysfunction resulting from lymphedema.Melittin derived peptides for nanoparticle based siRNA transfection.Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy.The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy.Essential role of IL-10/STAT3 in chronic stress-induced immune suppression.Targeting STAT3 in gastric cancer.An overview of transcriptional regulation in response to toxicological insult.Anti-tumour strategies aiming to target tumour-associated macrophages.STAT3 activation: A key factor in tumor immunoescape.Dysregulation of JAK-STAT pathway in hematological malignancies and JAK inhibitors for clinical application.Oncogenic role and therapeutic target of leptin signaling in colorectal cancer.Methanethiosulfonate derivatives as ligands of the STAT3-SH2 domain.Endothelial STAT3 Activation Increases Vascular Leakage Through Downregulating Tight Junction Proteins: Implications for Diabetic Retinopathy.Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells.Signal transducer and activator of transcription 3 as a therapeutic target for cancer and the tumor microenvironment.Novel carbazole inhibits phospho-STAT3 through induction of protein-tyrosine phosphatase PTPN6.Targeting Inflammation in Cancer Prevention and Therapy.β-Caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP-1 protein tyrosine phosphatase.Biologic activity of the novel small molecule STAT3 inhibitor LLL12 against canine osteosarcoma cell lines.Disruption of STAT3-DNMT1 interaction by SH-I-14 induces re-expression of tumor suppressor genes and inhibits growth of triple-negative breast tumor.Nitidine chloride acts as an apoptosis inducer in human oral cancer cells and a nude mouse xenograft model via inhibition of STAT3.STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo.Crocin Suppresses Constitutively Active STAT3 Through Induction of Protein Tyrosine Phosphatase SHP-1.Targeting a phospho-STAT3-miRNAs pathway improves vesicular hepatic steatosis in an in vitro and in vivo modelA novel small inhibitor, LLL12, targets STAT3 in non-small cell lung cancer and
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P2860
Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Inhibiting signal transducer a ...... ationale design of inhibitors.
@ast
Inhibiting signal transducer a ...... ationale design of inhibitors.
@en
type
label
Inhibiting signal transducer a ...... ationale design of inhibitors.
@ast
Inhibiting signal transducer a ...... ationale design of inhibitors.
@en
prefLabel
Inhibiting signal transducer a ...... ationale design of inhibitors.
@ast
Inhibiting signal transducer a ...... ationale design of inhibitors.
@en
P2860
P1476
Inhibiting signal transducer a ...... ationale design of inhibitors.
@en
P2093
Arun K Mankan
P2860
P304
P356
10.1517/13543784.2011.601739
P407
P577
2011-07-14T00:00:00Z