Targeted disruption of the murine fps/fes proto-oncogene reveals that Fps/Fes kinase activity is dispensable for hematopoiesis.
about
A point mutation in the N-terminal coiled-coil domain releases c-Fes tyrosine kinase activity and survival signaling in myeloid leukemia cellsClosing in on the biological functions of Fps/Fes and FerThe Fer tyrosine kinase regulates an axon retraction response to Semaphorin 3A in dorsal root ganglion neurons.Fer and Fps/Fes participate in a Lyn-dependent pathway from FcepsilonRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activationFer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cellsThe KRAB-associated co-repressor KAP-1 is a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase.Hemostatic and hematological abnormalities in gain-of-function fps/fes transgenic mice are associated with the angiogenic phenotype.Control of myeloid differentiation and survival by Stats.Mice devoid of fer protein-tyrosine kinase activity are viable and fertile but display reduced cortactin phosphorylation.Enhanced endotoxin sensitivity in fps/fes-null mice with minimal defects in hematopoietic homeostasis.Activated Fes protein tyrosine kinase induces terminal macrophage differentiation of myeloid progenitors (U937 cells) and activation of the transcription factor PU.1.Fes tyrosine kinase expression in the tumor niche correlates with enhanced tumor growth, angiogenesis, circulating tumor cells, metastasis, and infiltrating macrophages.FES-Cre targets phosphatidylinositol glycan class A (PIGA) inactivation to hematopoietic stem cells in the bone marrowVascular defects in gain-of-function fps/fes transgenic mice correlate with PDGF- and VEGF-induced activation of mutant Fps/Fes kinase in endothelial cells.Fps/Fes and Fer non-receptor protein-tyrosine kinases regulate collagen- and ADP-induced platelet aggregation.Conditional disruption of ubiquitous calpains in the mouse.
P2860
Q24291572-AACE247E-22C0-4179-8849-681AFB3DC6A5Q24296817-98160A81-B876-495A-AF67-5E484279BBC3Q24301983-BB43FCC2-0F80-49DE-85C6-A40419569FC7Q28590899-344701C8-A0A2-47EE-B1E9-8EA38BBD64C6Q28593250-A4B5FAC3-C688-4329-BF67-983DFB4C735AQ33247592-EDA845D9-0C86-41FC-ABE5-70CAE74CAD50Q33363746-632FCFDC-7DD6-4CA4-B127-247804E49A7AQ33941411-D078C0D8-C604-4038-A5AB-94642A104AECQ33966983-401A1D11-2F8A-4907-AB61-7DEC2360892AQ34277301-E73676D3-F8AB-4144-A529-65C8DB7BA57CQ34323999-020B572E-FA5D-4775-B048-ACB64574A683Q34586664-D6B67423-AD42-4B6B-8B89-BE9A294FEBA0Q36376285-AE8B04D6-8D07-4BD1-B6DF-CCB1023DC2A3Q40564560-573BA55E-EC38-4C31-B214-ABFD9ADF19FAQ44518823-CC26A8D3-20C6-461B-B3F2-DB5E5EBB2349Q52571542-59BD5FA2-1280-4C6C-A652-2AAD25DC126B
P2860
Targeted disruption of the murine fps/fes proto-oncogene reveals that Fps/Fes kinase activity is dispensable for hematopoiesis.
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Targeted disruption of the mur ...... dispensable for hematopoiesis.
@ast
Targeted disruption of the mur ...... dispensable for hematopoiesis.
@en
type
label
Targeted disruption of the mur ...... dispensable for hematopoiesis.
@ast
Targeted disruption of the mur ...... dispensable for hematopoiesis.
@en
prefLabel
Targeted disruption of the mur ...... dispensable for hematopoiesis.
@ast
Targeted disruption of the mur ...... dispensable for hematopoiesis.
@en
P2093
P2860
P356
P1476
Targeted disruption of the mur ...... dispensable for hematopoiesis
@en
P2093
P2860
P304
P356
10.1128/MCB.19.11.7436
P407
P577
1999-11-01T00:00:00Z