about
Selective impairment of platelet activation to collagen in the absence of GATA1The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosisMice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet functionG6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen.A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif proteinTargeted disruption of the murine fps/fes proto-oncogene reveals that Fps/Fes kinase activity is dispensable for hematopoiesis.Enhanced endotoxin sensitivity in fps/fes-null mice with minimal defects in hematopoietic homeostasis.Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis.Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome"Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.Minimal regulation of platelet activity by PECAM-1.Platelet proteomics: state of the art and future perspective.Protein-tyrosine phosphatases: a new frontier in platelet signal transduction.Src family kinases: at the forefront of platelet activationITIM receptors: more than just inhibitors of platelet activation.Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signalingA global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter.Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in plateletsCD148 enhances platelet responsiveness to collagen by maintaining a pool of active Src family kinases.Fps/Fes and Fer protein-tyrosinekinases play redundant roles in regulating hematopoiesis.Maintenance of murine platelet homeostasis by the kinase Csk and the phosphatase CD148.Mice Lacking the Inhibitory Collagen Receptor LAIR-1 Exhibit a Mild Thrombocytosis and Hyperactive Platelets.Cross talk between serine/threonine and tyrosine kinases regulates ADP-induced thromboxane generation in platelets.Dominant role of the protein-tyrosine phosphatase CD148 in regulating platelet activation relative to protein-tyrosine phosphatase-1B.Evaluation of the Total Thrombus-Formation System (T-TAS): application to human and mouse blood analysisTREM-like transcript 1: a more sensitive marker of platelet activation than P-selectin in humans and miceCongenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized miceCollagen type I degradation fragments act through the collagen receptor LAIR-1 to provide a negative feedback for osteoclast formationUncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasisProplatelets slip slidin' awaySignalling through Src family kinase isoforms is not redundant in models of thrombo-inflammatory vascular diseaseThe transgenic mouse: a new model to delineate platelet and leukocyte functionsCell layer-specific expression of cyclic nucleotide phosphodiesterases in rat arteries: molecular cloning using isolated cell layers from paraformaldehyde-fixed tissuesChanges in the pattern of distribution of von Willebrand factor in rat aortic endothelial cells following thrombin generation in vivoMorphological alterations in endothelial cells associated with the release of von Willebrand factor after thrombin generation in vivoAbsence of Fer protein-tyrosine kinase exacerbates leukocyte recruitment in response to endotoxinHeparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-BTargeting Receptor-Type Protein Tyrosine Phosphatases with Biotherapeutics: Is Outside-in Better than Inside-Out?Ups and downs of the ADP phosphoproteome
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P31
P496
0000-0002-0947-9957