Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin.
about
Human perforin employs different avenues to damage membranesPerforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells.Genes involved in pancreatic islet cell rejuvenationNK cell therapy: targeting disease relapse after hematopoietic stem cell transplantationAre BiTEs the "missing link" in cancer therapy?Granzyme M mediates a novel form of perforin-dependent cell deathListeriolysin o is strongly immunogenic independently of its cytotoxic activityCytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.Imaging of lytic granule exocytosis in CD8+ cytotoxic T lymphocytes reveals a modified form of full fusion.Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity.Granzyme A- and B-cluster deficiency delays acute lung injury in pneumovirus-infected miceCationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells.Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage.Perforin rapidly induces plasma membrane phospholipid flip-flopDiscordant regulation of granzyme H and granzyme B expression in human lymphocytes.Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infectionDeath by a thousand cuts: granzyme pathways of programmed cell deathPerforin: more than just a pore-forming protein.Perforin: structure, function, and role in human immunopathology.Japanese encephalitis virus infection induces changes of mRNA profile of mouse spleen and brain.A triple-mutated allele of granzyme B incapable of inducing apoptosis.Endocytosing the death sentenceToxoplasma gondii inhibits granzyme B-mediated apoptosis by the inhibition of granzyme B function in host cellsNonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6.Perforin and lymphohistiocytic proliferative disorders.Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosisA clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death.Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.Resistance to granzyme B-mediated cytochrome c release in Bak-deficient cells.The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene.Repair of injured plasma membrane by rapid Ca2+-dependent endocytosis.Granzymes drive a rapid listeriolysin O-induced T cell apoptosisThe cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression.Natural killer cell-based immunotherapy in cancer: current insights and future prospects.The battlefield of perforin/granzyme cell death pathways.The perforin pore facilitates the delivery of cationic cargos.Functional dissection of the granzyme family: cell death and inflammation.Controversies in granzyme biology.Immunotoxins constructed with ribosome-inactivating proteins and their enhancers: a lethal cocktail with tumor specific efficacy.Granzyme K-deficient mice show no evidence of impaired antiviral immunity.
P2860
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P2860
Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin.
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Cytosolic delivery of granzyme ...... mportant function of perforin.
@ast
Cytosolic delivery of granzyme ...... mportant function of perforin.
@en
type
label
Cytosolic delivery of granzyme ...... mportant function of perforin.
@ast
Cytosolic delivery of granzyme ...... mportant function of perforin.
@en
prefLabel
Cytosolic delivery of granzyme ...... mportant function of perforin.
@ast
Cytosolic delivery of granzyme ...... mportant function of perforin.
@en
P2093
P2860
P356
P1476
Cytosolic delivery of granzyme ...... mportant function of perforin.
@en
P2093
P2860
P304
P356
10.1128/MCB.19.12.8604
P407
P577
1999-12-01T00:00:00Z