CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling network - Wikidata - wikimedia - TriplyDB

CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling network

CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling network

http://www.wikidata.org/entity/Q33961583

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Unravelling osteoarthritis-related synovial fibrosis: a step closer to solving joint stiffness Cutaneous wound healing: recruiting developmental pathways for regeneration CXCL12 induces connective tissue growth factor expression in human lung fibroblasts through the Rac1/ERK, JNK, and AP-1 pathways.P190B RhoGAP overexpression in the developing mammary epithelium induces TGFβ-dependent fibroblast activation Fibrosis, vascular activation, and immune abnormalities resembling systemic sclerosis in bleomycin-treated Fli-1-haploinsufficient mice Matrix-dependent perturbation of TGFβ signaling and disease GLUT10 deficiency leads to oxidative stress and non-canonical αvβ3 integrin-mediated TGFβ signalling associated with extracellular matrix disarray in arterial tortuosity syndrome skin fibroblasts CCN2 is required for recruitment of Sox2-expressing cells during cutaneous tissue repair.In vivo knockdown of intersectin-1s alters endothelial cell phenotype and causes microvascular remodeling in the mouse lungs The matricellular protein CCN1 enhances TGF-β1/SMAD3-dependent profibrotic signaling in fibroblasts and contributes to fibrogenic responses to lung injury.Twist1-related miR-26b-5p suppresses epithelial-mesenchymal transition, migration and invasion by targeting SMAD1 in hepatocellular carcinoma.Tumour cells down-regulate CCN2 gene expression in co-cultured fibroblasts in a Smad7- and ERK-dependent manner.ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma The Role of TGF-β Receptors in Fibrosis.Molecular regulation of CCN2 in the intervertebral disc: lessons learned from other connective tissues Transforming growth factor β--at the centre of systemic sclerosis.Scar management in burn injuries using drug delivery and molecular signaling: Current treatments and future directions.Molecular mechanisms of atrial fibrosis: implications for the clinic.Transcriptional and posttranscriptional regulation of CXCL8/IL-8 gene expression induced by connective tissue growth factor.MicroRNA-26b inhibits metastasis of osteosarcoma via targeting CTGF and Smad1.Parenchyma-stromal interactions induce fibrosis by secreting CCN2 and promote osteoclastogenesis by stimulating RANKL and CD68 through activated TGF-β/BMP4 in ameloblastoma.MEK/ERK inhibitors: proof-of-concept studies in lung fibrosis.Getting out of a sticky situation: targeting the myofibroblast in scleroderma Scleral fibroblast response to experimental glaucoma in mice Adiponectin Is Involved in Connective Tissue Growth Factor-Induced Proliferation, Migration and Overproduction of the Extracellular Matrix in Keloid Fibroblasts.Elevated expression of cav-1 in a subset of SSc fibroblasts contributes to constitutive Alk1/Smad1 activation.Integrins as Modulators of Transforming Growth Factor Beta Signaling in Dermal Fibroblasts During Skin Regeneration After Injury.The endothelin A receptor mediates fibrocyte differentiation in chronic obstructive asthma. The involvement of connective tissue growth factor.Fell-Muir lecture: Connective tissue growth factor (CCN2) -- a pernicious and pleiotropic player in the development of kidney fibrosis.Alteration of circulating miRNAs in SSc: miR-30b regulates the expression of PDGF receptor β.The Activation of Human Dermal Microvascular Cells by Poly(I:C), Lipopolysaccharide, Imiquimod, and ODN2395 Is Mediated by the Fli1/FOXO3A Pathway.Multifaced Roles of the αvβ3 Integrin in Ehlers-Danlos and Arterial Tortuosity Syndromes' Dermal Fibroblasts.CCN2 and CCN5 exerts opposing effect on fibroblast proliferation and transdifferentiation induced by TGF-β.TGF-ß induces Lysyl hydroxylase 2b in human synovial osteoarthritic fibroblasts through ALK5 signaling.Mechanical stretch down-regulates expression of the Smad6 gene in cultured rat mesangial cells.Tirosin kinase inhibitors in chronic graft versus host disease: from bench to bedside.Onset and Progression of Human Osteoarthritis-Can Growth Factors, Inflammatory Cytokines, or Differential miRNA Expression Concomitantly Induce Proliferation, ECM Degradation, and Inflammation in Articular Cartilage?

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CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling network

http://www.wikidata.org/entity/Q33961583

description

2011 nî lūn-bûn

@nan

2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հուլիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling network

@ast

CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling network

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type

label

CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling network

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CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling network

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prefLabel

CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling network

@ast

CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling network

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JOURNAL.PONE.0021911

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CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling network

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Andreea M Bujor

http://www.w3.org/2001/XMLSchema#string

Maria Trojanowska

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Sashidhar S Nakerakanti

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P2860

TGF-beta signal transduction

Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling

Integrin-regulated FAK-Src signaling in normal and cancer cells

Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo

uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180.

Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model

Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis

CCN2 is required for bleomycin-induced skin fibrosis in mice

Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor TrkA

Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells

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e21911

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